Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments

Protein Domains:

  1. 22181803-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 2218209Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. 2218210Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. 2218223Species Mouse (Mus musculus) [TaxId:10090] [56167] (7 PDB entries)
  3. 2218236Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. 2218253Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 2218333B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 2218339Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 2218343c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 2218391c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 2218400c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 2218401Species Chicken (Gallus gallus) [TaxId:9031] [56157] (48 PDB entries)
    2. 2218497Species Human (Homo sapiens) [TaxId:9606] [56156] (12 PDB entries)
  10. 2218515Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 2218518cAMP-dependent PK, catalytic subunit [56116] (5 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 2218519Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 2218521Species Cow (Bos taurus) [TaxId:9913] [56118] (40 PDB entries)
      Uniprot P00517
    3. 2218564Species Mouse (Mus musculus) [TaxId:10090] [56119] (30 PDB entries)
    4. 2218599Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    5. 2218601Species Pig (Sus scrofa) [TaxId:9823] [56117] (9 PDB entries)
  12. 2218614Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 2218626Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 2218627Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 2218632Species Human (Homo sapiens) [TaxId:9606] [224941] (14 PDB entries)
    3. 2218670Species Mouse (Mus musculus) [TaxId:10090] [197326] (2 PDB entries)
    4. 2218675Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 2218680Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 2218751Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. 2218757Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. 2218765Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 2218766Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
      Uniprot P24941
    2. 2219239Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. 2219248Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. 2219260Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. 2219278Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. 2219307Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  22. 2219336Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. 2219340EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. 2219456Endoribonuclease Ire1 [310779] (1 species)
    Pfam PF06478; Includes extra C-terminal alpha-helical KEN domain described in PubMed 18191223
  25. 2219460epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. 2219464ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  27. 2219468Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. 2219537Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  29. 2219576Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  30. 2219579Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. 2219580Species Chicken (Gallus gallus) [TaxId:9031] [187336] (2 PDB entries)
    2. 2219583Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)
  31. 2219606G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  32. 2219617gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  33. 2219622Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  34. 2219707Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  35. 2219750Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  36. 2219815Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. 2219839Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  38. 2219897Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  39. 2219935MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  40. 2219987MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2219988Species Human (Homo sapiens) [TaxId:9606] [56135] (31 PDB entries)
    2. 2220035Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (36 PDB entries)
  41. 2220075MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2220076Species Human (Homo sapiens) [TaxId:9606] [56130] (185 PDB entries)
    2. 2220279Species Mouse (Mus musculus) [TaxId:10090] [56131] (25 PDB entries)
  42. 2220305MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. 2220309Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  44. 2220313Multidrug tolerance (MDT) protein HipA N-terminal domain [310802] (1 species)
    Pfam PF13657; Pfam PF07804; Pfam PF07805 (in that order in the sequence)
  45. 2220327Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  46. 2220330Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  47. 2220339pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  48. 2220373Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  49. 2220395Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  50. 2220398Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 2220399Species Human (Homo sapiens) [TaxId:9606] [75559] (91 PDB entries)
    2. 2220534Species Maize (Zea mays) [TaxId:4577] [56143] (33 PDB entries)
    3. 2220573Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  51. 2220578Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase
  52. 2220589Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  53. 2220696Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  54. 2220699Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  55. 2220707Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  56. 2220711Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  57. 2220722STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  58. 2220729Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  59. 2220733Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  60. 2220737Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 2220738Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 2220740Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  61. 2220743Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  62. 2220777Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  63. 2220835Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  64. 2220907Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  65. 2220910Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  66. 2220941automated matches [190091] (17 species)
    not a true protein
    1. 2220942Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (11 PDB entries)
    2. 2220963Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    3. 2220966Species Chicken (Gallus gallus) [TaxId:9031] [187329] (14 PDB entries)
    4. 2220988Species Cow (Bos taurus) [TaxId:9913] [187007] (30 PDB entries)
    5. 2221032Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    6. 2221035Species Escherichia coli [TaxId:562] [311247] (1 PDB entry)
    7. 2221038Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [258686] (1 PDB entry)
    8. 2221040Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)
    9. 2221951Species Maize (Zea mays) [TaxId:4577] [195345] (1 PDB entry)
    10. 2221953Species Mouse (Mus musculus) [TaxId:10090] [187169] (38 PDB entries)
    11. 2222015Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    12. 2222019Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    13. 2222030Species Mycobacterium tuberculosis [TaxId:83332] [343222] (1 PDB entry)
    14. 2222032Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)
    15. 2222034Species Plasmodium falciparum [TaxId:36329] [336753] (1 PDB entry)
    16. 2222038Species Rattus norvegicus [TaxId:10116] [319413] (2 PDB entries)
    17. 2222041Species Saccharomyces cerevisiae [TaxId:559292] [339888] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: