Lineage for d5op4a_ (5op4 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2542825Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  7. 2542826Species Human (Homo sapiens) [TaxId:9606] [64405] (85 PDB entries)
  8. 2542891Domain d5op4a_: 5op4 A: [340583]
    automated match to d2ydia_
    complexed with a0t; mutant

Details for d5op4a_

PDB Entry: 5op4 (more details), 2 Å

PDB Description: structure of chk1 10-pt. mutant complex with aminopyrimidine lrrk2 inhibitor
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d5op4a_:

Sequence, based on SEQRES records: (download)

>d5op4a_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilkml
nhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records): (download)

>d5op4a_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdnikkeicilkmlnhenvikfy
ghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdi
kphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdv
wscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenps
aritipdikkdrwynkplk

SCOPe Domain Coordinates for d5op4a_:

Click to download the PDB-style file with coordinates for d5op4a_.
(The format of our PDB-style files is described here.)

Timeline for d5op4a_: