SCOPe is a database developed at the Berkeley Lab and UC Berkeley that extends SCOP (version 1). SCOPe classifies many structures released since SCOP 1.75 through a combination of automation and manual curation, and corrects some errors, aiming to have the same accuracy as the fully hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.
In addition to new SCOPe releases, the SCOPe website provides integrated access to data found in all releases of the SCOP and Astral databases that feature stable identifiers (i.e., those since release 1.55). A history of all changes between consecutive releases of SCOP and SCOPe is available under the Stats & History menu.
In order to facilitate use of SCOPe data by SCOP and Astral users, we provide SCOPe data in parseable files in the same formats as the SCOP and Astral databases. SCOPe uses the same stable identifiers (e.g., sunid, sid, sccs) as were used for prior releases of SCOP and Astral.
In SCOPe 2.06, we have continued to perform manual curation of new Folds, Superfamilies, and Families. We classified members of 65 Pfam families having the most structures (all those with at least 15 PDB entries) that had not previously had a classified representative in SCOP or SCOPe.
We have also moved cloning artifacts that we could identify (e.g., expression tags) to a new class (l: Artifacts) in order to separate them from the homology-based curations in the rest of the SCOPe hierarchy. Including such artifacts can result in similarity between non-homologous sequences. We separated 21,876 tags, with lengths ranging from 1 to 28 residues, from their original domains. Where possible, we kept the same sid and sunid identifiers for the trimmed domains. Note that not all tags are clearly annotated in the PDB, so we intend to improve our detection algorithm in future stable SCOPe releases. We also generated a new set of full-length Astral chain sequences based on PDB SEQRES records, with these tags removed, as well as nonredundant subsets of this set.
All data in SCOPe (including the data from older releases of SCOP and Astral) are freely available to all users.
There are several alternative pronunciations of the vowels in the word SCOPe. All are considered correct.