SCOPe 2.08: Domain d4ry4a_: 4ry4 A:

Lineage for d4ry4a_ (4ry4 A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:420174] [188905] (22 PDB entries)

8. Domain d4ry4a_: 4ry4 A: [309606]
   automated match to d3gnwb_
   mutant

Details for d4ry4a_

PDB Entry: 4ry4, 2.59 Å

PDB Description: C-terminal mutant (Y448F) of HCV/J4 RNA polymerase

PDB Compounds: (A:) HCV J4 RNA polymerase (NS5B)

SCOPe Domain Sequences for d4ry4a_:

Sequence; same for both SEQRES and ATOM records:

>d4ry4a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqifgacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsr

Timeline for d4ry4a_:

• d4ry4a_ first appeared in SCOPe 2.06
  
• d4ry4a_ appears in SCOPe 2.07