SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family e.8.1.4: RNA-dependent RNA-polymerase

  1. Root: SCOPe 2.06
  2. 2217451Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)
  3. 2220074Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 2220075Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 2220913Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 protein domains)

Protein Domains:

  1. 2220914Reovirus polymerase lambda3 [82841] (1 species)
    contains additional N-terminal domain (res. 1-380) and C-terminal "bracelet" domain (res. 891-1267)
  2. 2220921Viral RNA polymerase [56695] (18 species)
    1. 2220922Species Avian infectious bursal disease virus [TaxId:10995] [160955] (1 PDB entry)
      Uniprot Q9Q6Q5 31-804
    2. 2220924Species Bovine viral diarrhea virus [TaxId:11099] [103401] (3 PDB entries)
    3. 2220931Species Foot-and-mouth disease virus - type c [TaxId:12116] [187085] (9 PDB entries)
    4. 2220941Species Foot-and-mouth disease virus [TaxId:12110] [111302] (7 PDB entries)
      Uniprot Q9QCE4 1858-2327
    5. 2220951Species Hepatitis C virus isolate bk [TaxId:11105] [195056] (4 PDB entries)
    6. 2220960Species Hepatitis c virus isolate [TaxId:420174] [188905] (22 PDB entries)
    7. 2221003Species Hepatitis c virus subtype 1a [TaxId:31646] [189928] (4 PDB entries)
    8. 2221010Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)
    9. 2221147Species Hepatitis C virus [TaxId:356411] [193797] (2 PDB entries)
    10. 2221150Species Human poliovirus 1 [TaxId:12081] [256393] (8 PDB entries)
    11. 2221159Species Human rhinovirus 14, HRV-14 [TaxId:12131] [111301] (2 PDB entries)
      Uniprot P03303 1720-2179
    12. 2221162Species Human rhinovirus 16 [TaxId:31708] [188024] (2 PDB entries)
    13. 2221170Species Human rhinovirus 16, HRV-16 [TaxId:31708] [111300] (2 PDB entries)
      Uniprot Q82122 1694-2153
    14. 2221175Species Human rhinovirus 1B, HRV-1B [TaxId:12129] [111299] (2 PDB entries)
      Uniprot P12916 1698-2157
    15. 2221178Species Norwalk virus [TaxId:11983] [103400] (8 PDB entries)
    16. 2221189Species Poliovirus type 1, strain Mahoney [TaxId:12080] [56696] (12 PDB entries)
      Uniprot P03300 1748-2208
    17. 2221221Species Rabbit hemorrhagic disease virus [TaxId:11976] [69882] (2 PDB entries)
    18. 2288058Species Hepatitis c virus genotype 2a (isolate jfh-1) [TaxId:356411] [331359] (1 PDB entry)
  3. 2221226automated matches [190260] (27 species)
    not a true protein
    1. 2221227Species Bovine viral diarrhea virus [TaxId:11099] [255087] (1 PDB entry)
    2. 2221229Species Coxsackievirus b3 [TaxId:103903] [188493] (5 PDB entries)
    3. 2221235Species Coxsackievirus b3 [TaxId:12072] [271111] (10 PDB entries)
    4. 2221238Species Foot-and-mouth disease virus [TaxId:12120] [272422] (2 PDB entries)
    5. 2221241Species Hepatitis B virus [TaxId:10407] [259720] (1 PDB entry)
    6. 2221243Species Hepatitis c virus (isolate 1) [TaxId:11104] [261697] (1 PDB entry)
    7. 2221245Species Hepatitis C virus isolate bk [TaxId:11105] [188687] (11 PDB entries)
    8. 2221268Species Hepatitis c virus isolate hc-j6 [TaxId:11113] [189608] (1 PDB entry)
    9. 2221270Species Hepatitis c virus isolate hc-j8 [TaxId:11115] [188981] (2 PDB entries)
    10. 2221275Species Hepatitis c virus isolate [TaxId:420174] [188851] (1 PDB entry)
    11. 2221278Species Hepatitis c virus jfh-1 [TaxId:356411] [189047] (3 PDB entries)
    12. 2221285Species Hepatitis c virus subtype 1a [TaxId:31646] [189338] (1 PDB entry)
    13. 2221289Species Hepatitis c virus subtype 1b [TaxId:31647] [187148] (4 PDB entries)
    14. 2221298Species Hepatitis C virus [TaxId:11103] [187048] (44 PDB entries)
    15. 2221383Species Hepatitis C virus [TaxId:11105] [188793] (3 PDB entries)
    16. 2221389Species Hepatitis C virus [TaxId:333284] [188792] (1 PDB entry)
    17. 2221391Species Hepatitis C virus [TaxId:356411] [189609] (1 PDB entry)
    18. 2221393Species Hepatitis C virus [TaxId:420174] [189885] (4 PDB entries)
    19. 2221401Species Human coxsackievirus B3 [TaxId:12072] [193138] (3 PDB entries)
    20. 2221414Species Human coxsackievirus [TaxId:12072] [188608] (1 PDB entry)
    21. 2221416Species Human enterovirus 71 [TaxId:39054] [189988] (4 PDB entries)
    22. 2221421Species Human poliovirus 1 [TaxId:12081] [193135] (16 PDB entries)
    23. 2221443Species Human rhinovirus a16 [TaxId:31708] [193142] (1 PDB entry)
    24. 2221445Species Murine norovirus 1 [TaxId:223997] [189982] (8 PDB entries)
    25. 2221473Species Murine norovirus [TaxId:223997] [226374] (2 PDB entries)
    26. 2221480Species Norwalk-like virus [TaxId:95340] [260334] (1 PDB entry)
    27. 2288056Species Hepatitis c virus genotype 1b (isolate con1) [TaxId:333284] [331357] (7 PDB entries)

More info for Family e.8.1.4: RNA-dependent RNA-polymerase

Timeline for Family e.8.1.4: RNA-dependent RNA-polymerase: