SCOPe 2.06: Domain d4jtwa_: 4jtw A:

Lineage for d4jtwa_ (4jtw A:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (18 species)

7. Species Hepatitis c virus isolate [TaxId:420174] [188905] (22 PDB entries)

8. Domain d4jtwa_: 4jtw A: [253046]
   automated match to d3gnwb_
   protein/RNA complex; complexed with 1nu, gol, mg

Details for d4jtwa_

PDB Entry: 4jtw, 3 Å

PDB Description: Crystal structure of HCV NS5B polymerase in complex with coupound 1

PDB Compounds: (A:) Genome polyprotein

SCOPe Domain Sequences for d4jtwa_:

Sequence, based on SEQRES records:

>d4jtwa_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d4jtwa_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs

Timeline for d4jtwa_:

• d4jtwa_ first appeared in SCOPe 2.04
  
• d4jtwa_ appears in SCOPe 2.05
  
• d4jtwa_ appears in SCOPe 2.07
  
• d4jtwa_ appears in the current release, SCOPe 2.08