SCOPe 2.06: Domain d4ke5a_: 4ke5 A:

Lineage for d4ke5a_ (4ke5 A:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (18 species)

7. Species Hepatitis c virus isolate [TaxId:420174] [188905] (22 PDB entries)

8. Domain d4ke5a_: 4ke5 A: [224265]
   automated match to d4kbia_
   protein/RNA complex; complexed with 1pv

Details for d4ke5a_

PDB Entry: 4ke5, 2.11 Å

PDB Description: hcv ns5b gt1b n316y with gsk5852

PDB Compounds: (A:) HCV Polymerase

SCOPe Domain Sequences for d4ke5a_:

Sequence, based on SEQRES records:

>d4ke5a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasrldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d4ke5a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus isolate [TaxId: 420174]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipvagy
sggdiyhs

Timeline for d4ke5a_:

• d4ke5a_ first appeared in SCOPe 2.03
  
• d4ke5a_ appears in SCOPe 2.05
  
• d4ke5a_ appears in SCOPe 2.07
  
• d4ke5a_ appears in the current release, SCOPe 2.08