SCOPe 2.08: Domain d3b8ra1: 3b8r A:818-1171

Lineage for d3b8ra1 (3b8r A:818-1171)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (30 PDB entries)

8. Domain d3b8ra1: 3b8r A:818-1171 [172498]
   Other proteins in same PDB: d3b8ra2
   automated match to d1vr2a_
   complexed with 887, edo

Details for d3b8ra1

PDB Entry: 3b8r, 2.7 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a naphthamide inhibitor

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d3b8ra1:

Sequence, based on SEQRES records:

>d3b8ra1 d.144.1.7 (A:818-1171) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
erlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegaths
ehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvp
ykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdf
glardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspyp
gvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqan
aqqd

Sequence, based on observed residues (ATOM records):

>d3b8ra1 d.144.1.7 (A:818-1171) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
erlpydaskwefprdrlklgkplgqvieadafgidktatcrtvavkmlkegathsehral
mselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvap
edlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgllpl
kwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapd
yttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqd

Timeline for d3b8ra1:

• d3b8ra1 first appeared in SCOPe 2.01, called d3b8ra_
  
• d3b8ra1 appears in SCOPe 2.07