Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments

Proteins:

  1. 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [56167] (16 PDB entries)
  3. Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. c-src tyrosine kinase [56155] (3 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. Species Chicken (Gallus gallus) [TaxId:9031] [56157] (53 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [56156] (14 PDB entries)
    3. Species Mouse (Mus musculus) [TaxId:10090] [350472] (1 PDB entry)
  10. Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. cAMP-dependent PK, catalytic subunit [56116] (7 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. Species Cow (Bos taurus) [TaxId:9913] [56118] (40 PDB entries)
      Uniprot P00517
    3. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [346668] (32 PDB entries)
    4. Species Human (Homo sapiens) [TaxId:9606] [352703] (8 PDB entries)
    5. Species Mouse (Mus musculus) [TaxId:10090] [56119] (33 PDB entries)
    6. Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    7. Species Pig (Sus scrofa) [TaxId:9823] [56117] (3 PDB entries)
  12. Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)
    3. Species Mouse (Mus musculus) [TaxId:10090] [197326] (2 PDB entries)
    4. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [88856] (414 PDB entries)
      Uniprot P24941
    2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
      Uniprot Q02750 61-381
    2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [390304] (6 PDB entries)
  22. Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. Endoribonuclease Ire1 [310779] (1 species)
    Pfam PF06478; Includes extra C-terminal alpha-helical KEN domain described in PubMed 18191223
  25. epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  27. Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  29. Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  30. Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. Species Chicken (Gallus gallus) [TaxId:9031] [187336] (5 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [103293] (23 PDB entries)
  31. G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  32. gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  33. Glycogen synthase kinase-3 beta (Gsk3b) [69823] (2 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [69824] (56 PDB entries)
      Uniprot P49841 35-383 ! Uniprot P49841 35-384
    2. Species Mouse (Mus musculus) [TaxId:10090] [357651] (1 PDB entry)
  34. Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  35. Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  36. Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  38. Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  39. MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  40. MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [56135] (73 PDB entries)
    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (58 PDB entries)
  41. MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [56131] (111 PDB entries)
  42. MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  44. Multidrug tolerance (MDT) protein HipA N-terminal domain [310802] (1 species)
    Pfam PF13657; Pfam PF07804; Pfam PF07805 (in that order in the sequence)
  45. Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  46. Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  47. pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  48. Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  49. Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  50. Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [75559] (180 PDB entries)
    2. Species Maize (Zea mays) [TaxId:4577] [56143] (33 PDB entries)
    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  51. Protein kinase wnk1 [111196] (2 species)
    OPK group; WNK subfamily; serine/threonine kinase
    1. Species Human (Homo sapiens) [TaxId:9606] [111197] (4 PDB entries)
      Uniprot Q9JIH7 211-480
    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [419788] (4 PDB entries)
  52. Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  53. Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  54. Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  55. Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  56. Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  57. STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  58. Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  59. Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  60. Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  61. Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  62. Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  63. Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  64. Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  65. Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  66. automated matches [190091] (20 species)
    not a true protein
    1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (11 PDB entries)
    2. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [383877] (5 PDB entries)
    3. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    4. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [339888] (1 PDB entry)
    5. Species Candida albicans [TaxId:237561] [367188] (3 PDB entries)
    6. Species Chicken (Gallus gallus) [TaxId:9031] [187329] (14 PDB entries)
    7. Species Cow (Bos taurus) [TaxId:9913] [187007] (28 PDB entries)
    8. Species Cryptococcus neoformans [TaxId:1230076] [376374] (6 PDB entries)
    9. Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    10. Species Escherichia coli [TaxId:562] [311247] (1 PDB entry)
    11. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [258686] (1 PDB entry)
    12. Species Human (Homo sapiens) [TaxId:9606] [188447] (844 PDB entries)
    13. Species Maize (Zea mays) [TaxId:4577] [195345] (2 PDB entries)
    14. Species Mouse (Mus musculus) [TaxId:10090] [187169] (30 PDB entries)
    15. Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    16. Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    17. Species Mycobacterium tuberculosis [TaxId:83332] [343222] (2 PDB entries)
    18. Species Norway rat (Rattus norvegicus) [TaxId:10116] [319413] (1 PDB entry)
    19. Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)
    20. Species Plasmodium falciparum [TaxId:36329] [336753] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: