Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2979545Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2979546Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2979693Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments

Proteins:

  1. 29796943-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 2979723Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. 2979724Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. 2979737Species Mouse (Mus musculus) [TaxId:10090] [56167] (16 PDB entries)
  3. 2979767Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. 2979788Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 2979877B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 2979883Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 2979887c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 2979947c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 2979972c-src tyrosine kinase [56155] (3 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 2979973Species Chicken (Gallus gallus) [TaxId:9031] [56157] (56 PDB entries)
    2. 2980081Species Human (Homo sapiens) [TaxId:9606] [56156] (14 PDB entries)
    3. 2980108Species Mouse (Mus musculus) [TaxId:10090] [350472] (1 PDB entry)
  10. 2980110Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 2980113cAMP-dependent PK, catalytic subunit [56116] (7 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 2980114Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 2980116Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [346668] (33 PDB entries)
    3. 2980149Species Cow (Bos taurus) [TaxId:9913] [56118] (40 PDB entries)
      Uniprot P00517
    4. 2980192Species Human (Homo sapiens) [TaxId:9606] [352703] (8 PDB entries)
    5. 2980203Species Mouse (Mus musculus) [TaxId:10090] [56119] (33 PDB entries)
    6. 2980243Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    7. Species Pig (Sus scrofa) [TaxId:9823] [56117] (3 PDB entries)
  12. 2980250Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 2980262Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 2980263Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 2980268Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)
    3. 2980329Species Mouse (Mus musculus) [TaxId:10090] [197326] (2 PDB entries)
    4. 2980334Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 2980339Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 2980447Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. 2980453Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. 2980461Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 2980462Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
      Uniprot P24941
    2. 2980981Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. 2980990Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. 2981002Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. 2981022Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. 2981059Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
    1. 2981060Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
      Uniprot Q02750 61-381
    2. 2981103Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [390304] (6 PDB entries)
  22. 2981110Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. 2981114EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. 2981328Endoribonuclease Ire1 [310779] (1 species)
    Pfam PF06478; Includes extra C-terminal alpha-helical KEN domain described in PubMed 18191223
  25. 2981332epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. 2981336ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  27. 2981340Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. 2981442Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  29. 2981481Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  30. 2981484Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. 2981485Species Chicken (Gallus gallus) [TaxId:9031] [187336] (5 PDB entries)
    2. 2981492Species Human (Homo sapiens) [TaxId:9606] [103293] (23 PDB entries)
  31. 2981539G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  32. 2981554gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  33. 2981559Glycogen synthase kinase-3 beta (Gsk3b) [69823] (2 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
    1. 2981560Species Human (Homo sapiens) [TaxId:9606] [69824] (57 PDB entries)
      Uniprot P49841 35-383 ! Uniprot P49841 35-384
    2. 2981666Species Mouse (Mus musculus) [TaxId:10090] [357651] (1 PDB entry)
  34. 2981671Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  35. 2981716Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  36. 2981797Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. 2981821Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  38. 2981879Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  39. 2981918MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  40. 2981976MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2981977Species Human (Homo sapiens) [TaxId:9606] [56135] (74 PDB entries)
    2. 2982066Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (58 PDB entries)
  41. 2982128MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2982129Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)
    2. 2982351Species Mouse (Mus musculus) [TaxId:10090] [56131] (111 PDB entries)
  42. 2982466MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. 2982470Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  44. 2982474Multidrug tolerance (MDT) protein HipA N-terminal domain [310802] (1 species)
    Pfam PF13657; Pfam PF07804; Pfam PF07805 (in that order in the sequence)
  45. 2982488Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  46. 2982491Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  47. 2982501pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  48. 2982535Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  49. 2982557Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  50. 2982560Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 2982561Species Human (Homo sapiens) [TaxId:9606] [75559] (184 PDB entries)
    2. 2982813Species Maize (Zea mays) [TaxId:4577] [56143] (33 PDB entries)
    3. 2982852Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  51. 2982857Protein kinase wnk1 [111196] (2 species)
    OPK group; WNK subfamily; serine/threonine kinase
    1. 2982858Species Human (Homo sapiens) [TaxId:9606] [111197] (4 PDB entries)
      Uniprot Q9JIH7 211-480
    2. 2982866Species Norway rat (Rattus norvegicus) [TaxId:10116] [419788] (4 PDB entries)
  52. 2982873Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  53. 2982999Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  54. 2983002Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  55. 2983010Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  56. 2983014Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  57. 2983025STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  58. 2983032Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  59. 2983036Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  60. 2983040Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 2983041Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 2983043Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  61. 2983046Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  62. 2983087Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  63. 2983145Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  64. 2983231Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  65. 2983234Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  66. 2983276automated matches [190091] (20 species)
    not a true protein
    1. 2983277Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (11 PDB entries)
    2. 2983298Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    3. 2983301Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [339888] (1 PDB entry)
    4. 2983304Species Candida albicans [TaxId:237561] [367188] (3 PDB entries)
    5. 2983309Species Chicken (Gallus gallus) [TaxId:9031] [187329] (14 PDB entries)
    6. 2983331Species Cow (Bos taurus) [TaxId:9913] [187007] (28 PDB entries)
    7. 2983373Species Cryptococcus neoformans [TaxId:1230076] [376374] (6 PDB entries)
    8. 2983381Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    9. 2983384Species Escherichia coli [TaxId:562] [311247] (1 PDB entry)
    10. 2983387Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [258686] (1 PDB entry)
    11. 2983389Species Human (Homo sapiens) [TaxId:9606] [188447] (849 PDB entries)
    12. 2984613Species Maize (Zea mays) [TaxId:4577] [195345] (2 PDB entries)
    13. 2984616Species Mouse (Mus musculus) [TaxId:10090] [187169] (30 PDB entries)
    14. 2984664Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    15. 2984668Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    16. 2984679Species Mycobacterium tuberculosis [TaxId:83332] [343222] (2 PDB entries)
    17. 2984683Species Norway rat (Rattus norvegicus) [TaxId:10116] [319413] (1 PDB entry)
    18. 2984685Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)
    19. 2984687Species Plasmodium falciparum [TaxId:36329] [336753] (1 PDB entry)
    20. 2984691Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [383877] (5 PDB entries)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: