Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments

Protein Domains:

  1. 21956913-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 2195720Abelsone tyrosine kinase (abl) [56166] (2 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. 2195721Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)
    2. 2195734Species Mouse (Mus musculus) [TaxId:10090] [56167] (7 PDB entries)
  3. 2195747Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. 2195764Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 2195828B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 2195834Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 2195838c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 2195886c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 2195895c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 2195896Species Chicken (Gallus gallus) [TaxId:9031] [56157] (48 PDB entries)
    2. 2195975Species Human (Homo sapiens) [TaxId:9606] [56156] (12 PDB entries)
  10. 2195993Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 2195996cAMP-dependent PK, catalytic subunit [56116] (5 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 2195997Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 2195999Species Cow (Bos taurus) [TaxId:9913] [56118] (40 PDB entries)
      Uniprot P00517
    3. 2196042Species Mouse (Mus musculus) [TaxId:10090] [56119] (30 PDB entries)
    4. 2196077Species Norway rat (Rattus norvegicus) [TaxId:10116] [256101] (1 PDB entry)
    5. 2196079Species Pig (Sus scrofa) [TaxId:9823] [56117] (9 PDB entries)
  12. 2196092Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 2196104Casein kinase-1, CK1 [56139] (4 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 2196105Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 2196110Species Human (Homo sapiens) [TaxId:9606] [224941] (14 PDB entries)
    3. 2196135Species Mouse (Mus musculus) [TaxId:10090] [197326] (2 PDB entries)
    4. 2196138Species Norway rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 2196143Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 2196214Cell division protein kinase 7, CDK7 [118139] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  16. 2196220Cell division protein kinase 9, CDK9 [160810] (1 species)
  17. 2196228Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 2196229Species Human (Homo sapiens) [TaxId:9606] [88856] (373 PDB entries)
      Uniprot P24941
    2. 2196678Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
  18. 2196687Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  19. 2196699Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  20. 2196717Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  21. 2196746Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  22. 2196774Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  23. 2196778EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  24. 2196860Endoribonuclease Ire1 [310779] (1 species)
    Pfam PF06478; Includes extra C-terminal alpha-helical KEN domain described in PubMed 18191223
  25. 2196864epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  26. 2196868ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  27. 2196872Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  28. 2196928Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  29. 2196967Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  30. 2196970Focal adhesion kinase 1 (fak) [103292] (2 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. 2196971Species Chicken (Gallus gallus) [TaxId:9031] [187336] (2 PDB entries)
    2. 2196974Species Human (Homo sapiens) [TaxId:9606] [103293] (15 PDB entries)
  31. 2196997G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  32. 2197008gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  33. 2197013Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  34. 2197088Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  35. 2197126Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  36. 2197176Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  37. 2197199Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  38. 2197249Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  39. 2197287MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  40. 2197339MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2197340Species Human (Homo sapiens) [TaxId:9606] [56135] (31 PDB entries)
    2. 2197378Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (36 PDB entries)
  41. 2197409MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 2197410Species Human (Homo sapiens) [TaxId:9606] [56130] (185 PDB entries)
    2. 2197597Species Mouse (Mus musculus) [TaxId:10090] [56131] (25 PDB entries)
  42. 2197621MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  43. 2197625Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  44. 2197629Multidrug tolerance (MDT) protein HipA N-terminal domain [310802] (1 species)
    Pfam PF13657; Pfam PF07804; Pfam PF07805 (in that order in the sequence)
  45. 2197643Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  46. 2197646Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  47. 2197655pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  48. 2197688Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  49. 2197710Protein kinase C, theta type [118129] (1 species)
    AGC group; PKC subfamily; serine/threonine kinase
  50. 2197713Protein kinase CK2, alpha subunit [56142] (3 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 2197714Species Human (Homo sapiens) [TaxId:9606] [75559] (91 PDB entries)
    2. 2197779Species Maize (Zea mays) [TaxId:4577] [56143] (33 PDB entries)
    3. 2197818Species Norway rat (Rattus norvegicus) [TaxId:10116] [160809] (1 PDB entry)
  51. 2197823Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase
  52. 2197828Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
    OPK group(?); PIM subfamily; serine/threonine kinase
  53. 2197918Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  54. 2197921Serine/threonine protein kinase TAO2 [118127] (1 species)
    OPK group; serine/threonine kinase
  55. 2197929Serine/threonine-protein kinase Nek2 [143893] (1 species)
    NIMA subfamily (NimA-related protein kinase 2)
  56. 2197933Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  57. 2197944STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  58. 2197951Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  59. 2197955Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  60. 2197959Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 2197960Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 2197962Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  61. 2197965Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  62. 2197991Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  63. 2198049Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  64. 2198110Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  65. 2198113Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  66. 2198144automated matches [190091] (16 species)
    not a true protein
    1. 2198145Species African clawed frog (Xenopus laevis) [TaxId:8355] [187456] (11 PDB entries)
    2. 2198162Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187909] (1 PDB entry)
    3. 2198165Species Chicken (Gallus gallus) [TaxId:9031] [187329] (14 PDB entries)
    4. 2198187Species Cow (Bos taurus) [TaxId:9913] [187007] (30 PDB entries)
    5. 2198229Species Cryptosporidium parvum [TaxId:353152] [188006] (2 PDB entries)
    6. 2198232Species Escherichia coli [TaxId:562] [311247] (1 PDB entry)
    7. 2198235Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [258686] (1 PDB entry)
    8. 2198237Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)
    9. 2198975Species Maize (Zea mays) [TaxId:4577] [195345] (1 PDB entry)
    10. 2198977Species Mouse (Mus musculus) [TaxId:10090] [187169] (38 PDB entries)
    11. 2199036Species Mycobacterium tuberculosis [TaxId:1773] [225570] (2 PDB entries)
    12. 2199040Species Mycobacterium tuberculosis [TaxId:419947] [226040] (7 PDB entries)
    13. 2199051Species Oryza sativa [TaxId:39947] [256089] (1 PDB entry)
    14. 2276112Species Rattus norvegicus [TaxId:10116] [319413] (2 PDB entries)
    15. 2293452Species Plasmodium falciparum [TaxId:36329] [336753] (1 PDB entry)
    16. 2296587Species Saccharomyces cerevisiae [TaxId:559292] [339888] (1 PDB entry)

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: