SCOPe 2.04: Domain d3c09c2: 3c09 C:122-218

Lineage for d3c09c2 (3c09 C:122-218)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d3c09c2: 3c09 C:122-218 [155814]
   Other proteins in same PDB: d3c09a1, d3c09a2, d3c09c1, d3c09d1, d3c09d2, d3c09h1
   automatically matched to d1ngwb2
   complexed with bma, man, nag

Details for d3c09c2

PDB Entry: 3c09, 3.2 Å

PDB Description: crystal structure the fab fragment of matuzumab (fab72000) in complex with domain iii of the extracellular region of egfr

PDB Compounds: (C:) Matuzumab Fab Heavy chain

SCOPe Domain Sequences for d3c09c2:

Sequence, based on SEQRES records:

>d3c09c2 b.1.1.2 (C:122-218) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkk

Sequence, based on observed residues (ATOM records):

>d3c09c2 b.1.1.2 (C:122-218) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvyicnvnh
kpsntkvdkk

Timeline for d3c09c2:

• d3c09c2 first appeared in SCOP 1.75
  
• d3c09c2 appears in SCOPe 2.03
  
• d3c09c2 appears in SCOPe 2.05
  
• d3c09c2 appears in the current release, SCOPe 2.08