Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1510240Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1510241Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1513476Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

Proteins:

  1. 1513477beta2-microglobulin [88600] (5 species)
    1. 1513478Species Cow (Bos taurus) [TaxId:9913] [48946] (6 PDB entries)
    2. 1513489Species Human (Homo sapiens) [TaxId:9606] [88602] (369 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    3. 1514079Species Mouse (Mus musculus) [TaxId:10090] [88603] (168 PDB entries)
      Uniprot P01887
    4. 1514342Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    5. 1514352Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 1514356CD1, alpha-3 domain [88615] (5 species)
    1. 1514357Species Cow (Bos taurus) [TaxId:9913] [226527] (2 PDB entries)
    2. Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (5 PDB entries)
    3. 1514371Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (6 PDB entries)
    4. 1514380Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    5. 1514384Species Mouse (Mus musculus) [TaxId:10090] [88616] (9 PDB entries)
  3. 1514397Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 1514398Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 1514401Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 1514403Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 1514408Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 1514415Class I MHC, alpha-3 domain [88604] (4 species)
    1. 1514416Species Human (Homo sapiens) [TaxId:9606] [88605] (187 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 1514700Species Mouse (Mus musculus) [TaxId:10090] [88606] (103 PDB entries)
      Uniprot P01901 22-299
    3. 1514877Species Norway rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 1514882Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 1514885Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 1514886Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1514888Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1514893Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (37 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 1514949Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1514951Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (25 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1514991Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 1515012Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 1515013Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1515015Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1515020Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (40 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 1515081Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1515083Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (17 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1515110Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 1515131Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 1515132Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 1515134Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 1515140Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 1515147Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 1515152Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 1515158Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 1515164Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 1515169Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 1515176Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 1515183Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
    1. 1515184Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 1515187Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    3. 1515499Species Mouse (Mus musculus) [TaxId:10090] [88576] (415 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    4. 1516042Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    5. 1516056Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    6. 1516069Species Synthetic construct [TaxId:32630] [158874] (1 PDB entry)
  16. 1516071Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 1516072Species Human (Homo sapiens) [TaxId:9606] [88585] (35 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 1516139Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 1516142Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 1516145Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (3 PDB entries)
  17. 1516151Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 1516152Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 1516154Species Human (Homo sapiens) [TaxId:9606] [88590] (35 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 1516224Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 1516229Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 1516232Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (3 PDB entries)
  18. 1516238Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 1516253Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)
    1. 1516254Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    2. 1516485Species Mouse (Mus musculus) [TaxId:10090] [88567] (346 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    3. 1516938Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (5 PDB entries)
    4. 1516951Species Synthetic construct [TaxId:32630] [158871] (1 PDB entry)
  20. 1516956Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 1516957Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 1516960Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 1517041Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 1517069Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 1517073T-cell antigen receptor [49125] (7 species)
    1. 1517074Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (20 PDB entries)
    2. 1517104Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (29 PDB entries)
    3. 1517147Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 1517154Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 1517161Species Mouse (Mus musculus) [TaxId:10090] [226194] (2 PDB entries)
    6. 1517164Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    7. 1517185Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 1517214Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 1517226automated matches [190374] (9 species)
    not a true protein
    1. 1517227Species Chimpanzee (Pan troglodytes) [TaxId:9598] [226268] (1 PDB entry)
    2. 1517230Species Cow (Bos taurus) [TaxId:9913] [225911] (1 PDB entry)
    3. 1517235Species Escherichia coli [TaxId:562] [224854] (1 PDB entry)
    4. 1517240Species Human (Homo sapiens) [TaxId:9606] [187221] (385 PDB entries)
    5. 1517994Species Mouse (Mus musculus) [TaxId:10090] [224855] (343 PDB entries)
    6. 1518556Species Murinae, homo sapiens [TaxId:39107] [228176] (2 PDB entries)
    7. 1518561Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [226687] (2 PDB entries)
    8. 1518565Species Rattus norvegicus [TaxId:10116] [262079] (1 PDB entry)
    9. 1518572Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [226134] (4 PDB entries)

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):