Lineage for Fold b.1: Immunoglobulin-like beta-sandwich

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1510240Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands

Superfamilies:

  1. 1510241b.1.1: Immunoglobulin [48726] (5 families) (S)
  2. 1521239b.1.2: Fibronectin type III [49265] (2 families) (S)
  3. 1521809b.1.3: PKD domain [49299] (1 family) (S)
  4. 1521823b.1.4: beta-Galactosidase/glucuronidase domain [49303] (2 families) (S)
  5. 1522496b.1.5: Transglutaminase, two C-terminal domains [49309] (2 families) (S)
    automatically mapped to Pfam PF00927
  6. 1522582b.1.6: Cadherin-like [49313] (3 families) (S)
  7. 1522709b.1.7: Actinoxanthin-like [49319] (1 family) (S)
    automatically mapped to Pfam PF00960
  8. 1522748b.1.8: Cu,Zn superoxide dismutase-like [49329] (2 families) (S)
    has additional strand at N-terminus
  9. 1523313b.1.9: CBD9-like [49344] (3 families) (S)
    has additional strand at N-terminus; the active site in a similar topological location as the Cu,Zn SOD site
  10. 1523336b.1.10: Clathrin adaptor appendage domain [49348] (4 families) (S)
    contains an additional N-terminal strand
  11. 1523399b.1.11: PapD-like [49354] (3 families) (S)
    contains PP switch between strands D and C'
  12. 1523538b.1.12: Purple acid phosphatase, N-terminal domain [49363] (2 families) (S)
  13. 1523580b.1.13: Superoxide reductase-like [49367] (2 families) (S)
  14. 1523674b.1.14: Invasin/intimin cell-adhesion fragments [49373] (2 families) (S)
  15. 1523705b.1.15: Integrin domains [69179] (2 families) (S)
  16. 1523745b.1.16: Lamin A/C globular tail domain [74853] (2 families) (S)
  17. 1523769b.1.17: Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) [74863] (2 families) (S)
  18. 1523789b.1.18: E set domains [81296] (24 families) (S)
    "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
  19. 1524869b.1.19: Antigen MPT63/MPB63 (immunoprotective extracellular protein) [81982] (1 family) (S)
    automatically mapped to Pfam PF09167
  20. 1524874b.1.20: Tp47 lipoprotein, middle and C-terminal domains [81986] (1 family) (S)
  21. 1524882b.1.21: Fungal immunomodulatory protein, FIP [101542] (1 family) (S)
    automatically mapped to Pfam PF09259
  22. 1524894b.1.22: ASF1-like [101546] (1 family) (S)
    contains extra C-terminal strand
    automatically mapped to Pfam PF04729
  23. 1524925b.1.23: ApaG-like [110069] (1 family) (S)
  24. 1524941b.1.24: Accessory protein X4 (ORF8, ORF7a) [117066] (1 family) (S)
    automatically mapped to Pfam PF08779
  25. 1524949b.1.25: LEA14-like [117070] (1 family) (S)
  26. 1524954b.1.26: ICP-like [141066] (2 families) (S)
    topological variant with similarity to the Cupredoxin-like fold (49502) in the N-terminal region
  27. 1524975b.1.27: CalX-like [141072] (2 families) (S)
  28. 1525010b.1.28: NEAT domain-like [158911] (2 families) (S)
  29. 1525092b.1.29: Macroglobulin [254121] (8 families) (S)
    C3 MG domains possibly arose by gene duplication according to PubMed 16177781; PubMed 17608619; possibly related to immunoglobulins according to Pfam clan annotations
  30. 1525171b.1.30: Zn aminopeptidase insert domain [254133] (2 families) (S)
    same topology as (b.1.15.1)
  31. 1525210b.1.31: Fibronectin III-like [254143] (2 families) (S)
    Pfam PF14310; PubMed 20138890; unclear if related to Fibronectin type III (b.1.2)

More info for Fold b.1: Immunoglobulin-like beta-sandwich

Timeline for Fold b.1: Immunoglobulin-like beta-sandwich: