Class b: All beta proteins [48724] (176 folds) |
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
b.1.1: Immunoglobulin [48726] (5 families) |
b.1.2: Fibronectin type III [49265] (2 families) |
b.1.3: PKD domain [49299] (1 family) |
b.1.4: beta-Galactosidase/glucuronidase domain [49303] (2 families) |
b.1.5: Transglutaminase, two C-terminal domains [49309] (2 families) automatically mapped to Pfam PF00927 |
b.1.6: Cadherin-like [49313] (3 families) |
b.1.7: Actinoxanthin-like [49319] (1 family) automatically mapped to Pfam PF00960 |
b.1.8: Cu,Zn superoxide dismutase-like [49329] (2 families) has additional strand at N-terminus |
b.1.9: CBD9-like [49344] (3 families) has additional strand at N-terminus; the active site in a similar topological location as the Cu,Zn SOD site |
b.1.10: Clathrin adaptor appendage domain [49348] (4 families) contains an additional N-terminal strand |
b.1.11: PapD-like [49354] (3 families) contains PP switch between strands D and C' |
b.1.12: Purple acid phosphatase, N-terminal domain [49363] (2 families) |
b.1.13: Superoxide reductase-like [49367] (2 families) |
b.1.14: Invasin/intimin cell-adhesion fragments [49373] (2 families) |
b.1.15: Integrin domains [69179] (2 families) |
b.1.16: Lamin A/C globular tail domain [74853] (2 families) |
b.1.17: Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) [74863] (2 families) |
b.1.18: E set domains [81296] (24 families) "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies |
b.1.19: Antigen MPT63/MPB63 (immunoprotective extracellular protein) [81982] (1 family) automatically mapped to Pfam PF09167 |
b.1.20: Tp47 lipoprotein, middle and C-terminal domains [81986] (1 family) |
b.1.21: Fungal immunomodulatory protein, FIP [101542] (1 family) automatically mapped to Pfam PF09259 |
b.1.22: ASF1-like [101546] (1 family) contains extra C-terminal strand automatically mapped to Pfam PF04729 |
b.1.23: ApaG-like [110069] (1 family) |
b.1.24: Accessory protein X4 (ORF8, ORF7a) [117066] (1 family) automatically mapped to Pfam PF08779 |
b.1.25: LEA14-like [117070] (1 family) |
b.1.26: ICP-like [141066] (2 families) topological variant with similarity to the Cupredoxin-like fold (49502) in the N-terminal region |
b.1.27: CalX-like [141072] (2 families) |
b.1.28: NEAT domain-like [158911] (2 families) |
b.1.29: Macroglobulin [254121] (8 families) C3 MG domains possibly arose by gene duplication according to PubMed 16177781; PubMed 17608619; possibly related to immunoglobulins according to Pfam clan annotations |
b.1.30: Zn aminopeptidase insert domain [254133] (2 families) same topology as (b.1.15.1) |
b.1.31: Fibronectin III-like [254143] (2 families) Pfam PF14310; PubMed 20138890; unclear if related to Fibronectin type III (b.1.2) |
Timeline for Fold b.1: Immunoglobulin-like beta-sandwich: