PDB entry 6vqo

View 6vqo on RCSB PDB site
Description: T cell receptor-p53-HLA-A2 complex
Class: immune system
Keywords: TCR complex, MHC, HLA, adoptive cell therapy, IMMUNE SYSTEM
Deposited on 2020-02-05, released 2020-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vqoa1, d6vqoa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6vqob1, d6vqob2
  • Chain 'D':
    Compound: T-cell receptor 1a2, alfa chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO
    Domains in SCOPe 2.08: d6vqod1, d6vqod2
  • Chain 'E':
    Compound: TCR receptor 1a2, beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO
    Domains in SCOPe 2.08: d6vqoe1, d6vqoe2
  • Chain 'F':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6vqof1, d6vqof2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6vqog1, d6vqog2
  • Chain 'H':
    Compound: T-cell receptor 1a2, alfa chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO
    Domains in SCOPe 2.08: d6vqoh1, d6vqoh2
  • Chain 'J':
    Compound: TCR receptor 1a2, beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO
    Domains in SCOPe 2.08: d6vqoj1, d6vqoj2
  • Chain 'P':
    Compound: peptide from p53 tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO (0-8)
  • Chain 'Q':
    Compound: peptide from p53 tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6VQO (0-8)

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vqoA (A:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoA (A:)
shsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeywd
getrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydgk
dyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlqr
tdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgtf
qkwaavvvpsgqeqrytchvqheglpkpltlrw

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6vqoB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vqoD (D:)
mkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
ftaqvdksskyislfirdsqpsdsatylcamsglkedssyklifgsgtrllvrpdiqnpd
pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
nksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoD (D:)
keveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrf
taqvdksskyislfirdsqpsdsatylcamsglkedssyklifgsgtrllvrpdiqnpdp
avyqlrdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnfacan
afnnsiipedtff

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6vqoE (E:)
meaqvtqnprylitvtgkkltvtcsqnmnheymswyrqdpglglrqiyysmnvevtdkgd
vpegykvsrkekrnfplilespspnqtslyfcassiqqgadtqyfgpgtrltvledlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoE (E:)
qvtqnprylitvtgkkltvtcsqnmnheymswyrqdpglglrqiyysmnvevtdkgdvpe
gykvsrkekrnfplilespspnqtslyfcassiqqgadtqyfgpgtrltvledlknvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6vqoF (F:)
mgshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
wdgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyayd
gkdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketl
qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
tfqkwaavvvpsgqeqrytchvqheglpkpltlrweggglndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoF (F:)
shsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeywd
getrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydgk
dyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlqr
tdapkthrcwalsfypaeitltwqrdgedqtlvetrpagdgtfqkwaavvvpsgqeqryt
chvqheglpkpltl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6vqoG (G:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoG (G:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrd

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6vqoH (H:)
mkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
ftaqvdksskyislfirdsqpsdsatylcamsglkedssyklifgsgtrllvrpdiqnpd
pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
nksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoH (H:)
eveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrft
aqvdksskyislfirdsqpsdsatylcamsglkedssyklifgsgtrllvrpdiqnpdpa
vyqlrdsksksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksd
facanafnnsiipedt

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6vqoJ (J:)
meaqvtqnprylitvtgkkltvtcsqnmnheymswyrqdpglglrqiyysmnvevtdkgd
vpegykvsrkekrnfplilespspnqtslyfcassiqqgadtqyfgpgtrltvledlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
grad

    Sequence, based on observed residues (ATOM records): (download) 
    >6vqoJ (J:)
aqvtqnprylitvtgkkltvtcsqnmnheymswyrqdpglglrqiyysmnvevtdkgdvp
egykvsrkekrnfplilespspnqtslyfcassiqqgadtqyfgpgtrltvledlknvfp
pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
lndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgr
a

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.