Lineage for Protein: NADP-dependent isocitrate dehydrogenase

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1005388Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 1005389Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 1005390Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
    the active site is between the two identical subunits
  6. 1005475Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

Species:

  1. 1005476Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries)
    Uniprot O75874
    1. Domains for 1t09:
      1. 1005481Domain d1t09a_: 1t09 A: [106197]
        complexed with nap
      2. 1005482Domain d1t09b_: 1t09 B: [106198]
        complexed with nap
    2. Domains for 1t0l:
      1. 1005477Domain d1t0la_: 1t0l A: [106216]
        complexed with ca, ict, nap
      2. 1005478Domain d1t0lb_: 1t0l B: [106217]
        complexed with ca, ict, nap
      3. 1005479Domain d1t0lc_: 1t0l C: [106218]
        complexed with ca, ict, nap
      4. 1005480Domain d1t0ld_: 1t0l D: [106219]
        complexed with ca, ict, nap
  2. 1005483Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
    1. Domains for 1j1w:
      1. 1005486Domain d1j1wa_: 1j1w A: [90772]
        complexed with nap
      2. 1005487Domain d1j1wb_: 1j1w B: [90773]
        complexed with nap
      3. 1005488Domain d1j1wc_: 1j1w C: [90774]
        complexed with nap
      4. 1005489Domain d1j1wd_: 1j1w D: [90775]
        complexed with nap
    2. Domains for 1lwd:
      1. 1005484Domain d1lwda_: 1lwd A: [78265]
        complexed with ict, mn, so4
      2. 1005485Domain d1lwdb_: 1lwd B: [78266]
        complexed with ict, mn, so4

More info for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases:

  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases first appeared in SCOP 1.63
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOP 1.75
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.02
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in the current release, SCOPe 2.08