Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudo dyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) the constituent families form similar dimers |
Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins) the active site is between the two identical subunits |
Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species) |
Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries) Uniprot O75874 |
Domain d1t09a_: 1t09 A: [106197] complexed with nap |
Domain d1t09b_: 1t09 B: [106198] complexed with nap |
Domain d1t0la_: 1t0l A: [106216] complexed with ca, ict, nap |
Domain d1t0lb_: 1t0l B: [106217] complexed with ca, ict, nap |
Domain d1t0lc_: 1t0l C: [106218] complexed with ca, ict, nap |
Domain d1t0ld_: 1t0l D: [106219] complexed with ca, ict, nap |
Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries) |
Domain d1j1wa_: 1j1w A: [90772] complexed with nap |
Domain d1j1wb_: 1j1w B: [90773] complexed with nap |
Domain d1j1wc_: 1j1w C: [90774] complexed with nap |
Domain d1j1wd_: 1j1w D: [90775] complexed with nap |
Domain d1lwda_: 1lwd A: [78265] complexed with ict, mn, so4 |
Domain d1lwdb_: 1lwd B: [78266] complexed with ict, mn, so4 |
Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: