Lineage for Protein: NADP-dependent isocitrate dehydrogenase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 843892Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 843893Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) (S)
    the constituent families form similar dimers
  5. 843894Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
    the active site is between the two identical subunits
  6. 843981Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

Species:

  1. 843982Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries)
    Uniprot O75874
    1. Domains for 1t09:
      1. 843987Domain d1t09a_: 1t09 A: [106197]
      2. 843988Domain d1t09b_: 1t09 B: [106198]
        complexed with nap
    2. Domains for 1t0l:
      1. 843983Domain d1t0la_: 1t0l A: [106216]
      2. 843984Domain d1t0lb_: 1t0l B: [106217]
      3. 843985Domain d1t0lc_: 1t0l C: [106218]
      4. 843986Domain d1t0ld_: 1t0l D: [106219]
        complexed with ca, ict, nap
  2. 843989Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
    1. Domains for 1j1w:
      1. 843992Domain d1j1wa_: 1j1w A: [90772]
      2. 843993Domain d1j1wb_: 1j1w B: [90773]
      3. 843994Domain d1j1wc_: 1j1w C: [90774]
      4. 843995Domain d1j1wd_: 1j1w D: [90775]
        complexed with nap
    2. Domains for 1lwd:
      1. 843990Domain d1lwda_: 1lwd A: [78265]
      2. 843991Domain d1lwdb_: 1lwd B: [78266]
        complexed with ict, mn, so4

More info for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases:

  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases first appeared in SCOP 1.63
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOP 1.73
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.01
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in the current release, SCOPe 2.08