Lineage for Protein: E1-beta subunit of pyruvate dehydrogenase, Pyr module

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1844143Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 1844144Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 1844315Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 1844353Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)

Species:

  1. 1844354Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)
    1. Domains for 1ni4:
      1. 1844357Domain d1ni4b1: 1ni4 B:0-191 [85729]
        Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
        complexed with k, mg, tpp
      2. 1844358Domain d1ni4d1: 1ni4 D:0-191 [85732]
        Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
        complexed with k, mg, tpp
    2. Domains for 2ozl:
      1. 1844355Domain d2ozlb1: 2ozl B:0-191 [139447]
        Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2
        automated match to d1ni4b1
        complexed with k, mg, tpp
      2. 1844356Domain d2ozld1: 2ozl D:0-191 [139449]
        Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2
        automated match to d1ni4b1
        complexed with k, mg, tpp
    3. Domains for 3exf:
      1. 1844359Domain d3exfb1: 3exf B:1-191 [245929]
        Other proteins in same PDB: d3exfa_, d3exfb2, d3exfc_, d3exfd2, d3exfe_, d3exff2, d3exfg_, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      2. 1844360Domain d3exfd1: 3exf D:1-191 [245932]
        Other proteins in same PDB: d3exfa_, d3exfb2, d3exfc_, d3exfd2, d3exfe_, d3exff2, d3exfg_, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      3. 1844361Domain d3exff1: 3exf F:1-191 [245935]
        Other proteins in same PDB: d3exfa_, d3exfb2, d3exfc_, d3exfd2, d3exfe_, d3exff2, d3exfg_, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      4. 1844362Domain d3exfh1: 3exf H:1-191 [245938]
        Other proteins in same PDB: d3exfa_, d3exfb2, d3exfc_, d3exfd2, d3exfe_, d3exff2, d3exfg_, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
    4. Domains for 3exg:
      1. 1844363Domain d3exg21: 3exg 2:1-191 [245941]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      2. 1844364Domain d3exg41: 3exg 4:1-191 [245944]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      3. 1844365Domain d3exg61: 3exg 6:1-191 [245947]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      4. 1844366Domain d3exgb1: 3exg B:1-191 [245950]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      5. 1844367Domain d3exgd1: 3exg D:1-191 [245953]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      6. 1844368Domain d3exgf1: 3exg F:1-191 [245956]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      7. 1844369Domain d3exgh1: 3exg H:1-191 [245959]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      8. 1844370Domain d3exgj1: 3exg J:1-191 [245962]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      9. 1844371Domain d3exgl1: 3exg L:1-191 [245965]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      10. 1844372Domain d3exgn1: 3exg N:1-191 [245968]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      11. 1844373Domain d3exgp1: 3exg P:1-191 [245971]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      12. 1844374Domain d3exgr1: 3exg R:1-191 [245974]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      13. 1844375Domain d3exgt1: 3exg T:1-191 [245977]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      14. 1844376Domain d3exgv1: 3exg V:1-191 [245980]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      15. 1844377Domain d3exgx1: 3exg X:1-191 [245983]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
      16. 1844378Domain d3exgz1: 3exg Z:1-191 [245986]
        Other proteins in same PDB: d3exg1_, d3exg22, d3exg3_, d3exg42, d3exg5_, d3exg62, d3exga_, d3exgb2, d3exgc_, d3exgd2, d3exge_, d3exgf2, d3exgg_, d3exgh2, d3exgi_, d3exgj2, d3exgk_, d3exgl2, d3exgm_, d3exgn2, d3exgo_, d3exgp2, d3exgq_, d3exgr2, d3exgs_, d3exgt2, d3exgu_, d3exgv2, d3exgw_, d3exgx2, d3exgy_, d3exgz2
        automated match to d2ozlb1
        complexed with k
  2. 1844379Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)

More info for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: