Lineage for Protein: E1-beta subunit of pyruvate dehydrogenase, Pyr module

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2108468Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)

Species:

  1. 2108469Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)
    1. Domains for 1ni4:
      1. 2108472Domain d1ni4b1: 1ni4 B:1-191 [85729]
        Other proteins in same PDB: d1ni4a1, d1ni4a2, d1ni4b2, d1ni4b3, d1ni4c1, d1ni4c2, d1ni4d2, d1ni4d3
        complexed with k, mg, tpp
      2. 2108473Domain d1ni4d1: 1ni4 D:1-191 [85732]
        Other proteins in same PDB: d1ni4a1, d1ni4a2, d1ni4b2, d1ni4b3, d1ni4c1, d1ni4c2, d1ni4d2, d1ni4d3
        complexed with k, mg, tpp
    2. Domains for 2ozl:
      1. 2108470Domain d2ozlb1: 2ozl B:2-191 [139447]
        Other proteins in same PDB: d2ozla1, d2ozla2, d2ozlb2, d2ozlb3, d2ozlc2, d2ozlc3, d2ozld2, d2ozld3
        automated match to d1ni4b1
        complexed with k, mg, tpp
      2. 2108471Domain d2ozld1: 2ozl D:2-191 [139449]
        Other proteins in same PDB: d2ozla1, d2ozla2, d2ozlb2, d2ozlb3, d2ozlc2, d2ozlc3, d2ozld2, d2ozld3
        automated match to d1ni4b1
        complexed with k, mg, tpp
    3. Domains for 3exf:
      1. 2108474Domain d3exfb1: 3exf B:1-191 [245929]
        Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      2. 2108475Domain d3exfd1: 3exf D:1-191 [245932]
        Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      3. 2108476Domain d3exff1: 3exf F:1-191 [245935]
        Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
      4. 2108477Domain d3exfh1: 3exf H:1-191 [245938]
        Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
        automated match to d2ozlb1
        complexed with k, mg, tpp
    4. Domains for 3exg:
      1. 2108478Domain d3exg21: 3exg 2:1-191 [245941]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      2. 2108479Domain d3exg41: 3exg 4:1-191 [245944]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      3. 2108480Domain d3exg61: 3exg 6:1-191 [245947]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      4. 2108481Domain d3exgb1: 3exg B:1-191 [245950]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      5. 2108482Domain d3exgd1: 3exg D:1-191 [245953]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      6. 2108483Domain d3exgf1: 3exg F:1-191 [245956]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      7. 2108484Domain d3exgh1: 3exg H:1-191 [245959]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      8. 2108485Domain d3exgj1: 3exg J:1-191 [245962]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      9. 2108486Domain d3exgl1: 3exg L:1-191 [245965]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      10. 2108487Domain d3exgn1: 3exg N:1-191 [245968]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      11. 2108488Domain d3exgp1: 3exg P:1-191 [245971]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      12. 2108489Domain d3exgr1: 3exg R:1-191 [245974]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      13. 2108490Domain d3exgt1: 3exg T:1-191 [245977]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      14. 2108491Domain d3exgv1: 3exg V:1-191 [245980]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      15. 2108492Domain d3exgx1: 3exg X:1-191 [245983]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
      16. 2108493Domain d3exgz1: 3exg Z:1-191 [245986]
        Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
        automated match to d2ozlb1
        complexed with k
  2. 2108494Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)

More info for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: