SCOPe 2.08: Family d.32.1.3: Extradiol dioxygenases

Lineage for Family d.32.1.3: Extradiol dioxygenases

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
   beta-alpha-beta(3); 2 layers: alpha/beta

4. Superfamily d.32.1: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (11 families)

5. Family d.32.1.3: Extradiol dioxygenases [54602] (5 proteins)
   duplication: consists of 2 similar domains with 2 repeats in each
   Similar to the Methylmalonyl-CoA epimerase dimer

Proteins:

1. 2,3-Dihydroxybiphenyl dioxygenase (DHBD, BPHC enzyme) [54603] (2 species)

   1. Species Burkholderia cepacia, formerly Pseudomonas cepacia [TaxId:292] [54605] (6 PDB entries)

   2. Species Pseudomonas sp. [TaxId:306] [54604] (11 PDB entries)

2. 4-hydroxyphenylpyruvate dioxygenase, HppD [54608] (6 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [110878] (1 PDB entry)

   2. Species Maize (Zea mays) [TaxId:4577] [110879] (1 PDB entry)
      Uniprot O48604 29-423 # 85% sequence identity

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [256396] (1 PDB entry)
      Uniprot P32755

   4. Species Pseudomonas fluorescens [TaxId:294] [54609] (1 PDB entry)

   5. Species Streptomyces avermitilis [TaxId:33903] [110876] (1 PDB entry)
      Uniprot Q53586

   6. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [110877] (16 PDB entries)
      Uniprot P93836 33-428 ! Uniprot P93836 63-459

3. Catechol 2,3-dioxygenase (metapyrocatechase) [54606] (1 species)

   • Species Pseudomonas putida, mt2 [TaxId:303] [54607] (1 PDB entry)

4. Homoprotocatechuate 2,3-dioxygenase [89886] (2 species)

   1. Species Arthrobacter globiformis [TaxId:1665] [89887] (3 PDB entries)

   2. Species Brevibacterium fuscum [TaxId:47914] [89888] (17 PDB entries)

5. automated matches [276310] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [279455] (1 PDB entry)

   2. Species Pseudomonas sp. [311137] (1 PDB entry)

More info for Family d.32.1.3: Extradiol dioxygenases

Timeline for Family d.32.1.3: Extradiol dioxygenases:

• Family d.32.1.3: Extradiol dioxygenases first appeared (with stable ids) in SCOP 1.55
  
• Family d.32.1.3: Extradiol dioxygenases appears in SCOPe 2.07