Lineage for Protein: 4-hydroxyphenylpyruvate dioxygenase, HppD

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
    beta-alpha-beta(3); 2 layers: alpha/beta
  4. Superfamily d.32.1: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (11 families) (S)
  5. Family d.32.1.3: Extradiol dioxygenases [54602] (5 proteins)
    duplication: consists of 2 similar domains with 2 repeats in each
    Similar to the Methylmalonyl-CoA epimerase dimer
  6. Protein 4-hydroxyphenylpyruvate dioxygenase, HppD [54608] (6 species)

Species:

  1. Human (Homo sapiens) [TaxId:9606] [110878] (1 PDB entry)
  2. Maize (Zea mays) [TaxId:4577] [110879] (1 PDB entry)
    Uniprot O48604 29-423 # 85% sequence identity
  3. Norway rat (Rattus norvegicus) [TaxId:10116] [256396] (1 PDB entry)
    Uniprot P32755
  4. Pseudomonas fluorescens [TaxId:294] [54609] (1 PDB entry)
  5. Streptomyces avermitilis [TaxId:33903] [110876] (1 PDB entry)
    Uniprot Q53586
  6. Thale cress (Arabidopsis thaliana) [TaxId:3702] [110877] (14 PDB entries)
    Uniprot P93836 33-428 ! Uniprot P93836 63-459
    1. Domains for 1sp9:
      1. Domain d1sp9a1: 1sp9 A:33-232 [238534]
        complexed with fe2
      2. Domain d1sp9a2: 1sp9 A:233-428 [238535]
        complexed with fe2
      3. Domain d1sp9b1: 1sp9 B:33-193 [238536]
        automated match to d1tg5a1
        complexed with fe2
      4. Domain d1sp9b2: 1sp9 B:202-437 [238537]
        automated match to d1tg5a2
        complexed with fe2
    2. Domains for 1sqd:
      1. Domain d1sqda1: 1sqd A:14-195 [105906]
        complexed with fe
      2. Domain d1sqda2: 1sqd A:196-410 [105907]
        complexed with fe
    3. Domains for 1tfz:
      1. Domain d1tfza1: 1tfz A:15-195 [106886]
        complexed with 869, fe
      2. Domain d1tfza2: 1tfz A:196-408 [106887]
        complexed with 869, fe
    4. Domains for 1tg5:
      1. Domain d1tg5a1: 1tg5 A:14-195 [106890]
        complexed with 645, fe2
      2. Domain d1tg5a2: 1tg5 A:196-410 [106891]
        complexed with 645, fe2
    5. Domains for 5xgk:
      1. Domain d5xgka1: 5xgk A:29-232 [357805]
        automated match to d1sp9a1
        complexed with act, fe, tyf
      2. Domain d5xgka2: 5xgk A:233-437 [357806]
        automated match to d1sp9a2
        complexed with act, fe, tyf
      3. Domain d5xgkb1: 5xgk B:30-232 [357824]
        automated match to d1sp9a1
        complexed with act, fe, tyf
      4. Domain d5xgkb2: 5xgk B:233-434 [357825]
        automated match to d1sp9a2
        complexed with act, fe, tyf
      5. Domain d5xgkc1: 5xgk C:30-232 [357820]
        automated match to d1sp9a1
        complexed with act, fe, tyf
      6. Domain d5xgkc2: 5xgk C:233-439 [357821]
        automated match to d1sp9a2
        complexed with act, fe, tyf
      7. Domain d5xgkd1: 5xgk D:30-232 [357807]
        automated match to d1sp9a1
        complexed with act, fe, tyf
      8. Domain d5xgkd2: 5xgk D:233-436 [357808]
        automated match to d1sp9a2
        complexed with act, fe, tyf
    6. Domains for 5ywg:
      1. Domain d5ywga1: 5ywg A:29-232 [362509]
        automated match to d1sp9a1
        complexed with 92l, co
      2. Domain d5ywga2: 5ywg A:233-434 [362510]
        automated match to d1sp9a2
        complexed with 92l, co
      3. Domain d5ywgb1: 5ywg B:29-232 [362582]
        automated match to d1sp9a1
        complexed with 92l, co
      4. Domain d5ywgb2: 5ywg B:233-434 [362583]
        automated match to d1sp9a2
        complexed with 92l, co
    7. Domains for 5ywh:
      1. Domain d5ywha1: 5ywh A:29-232 [362601]
        automated match to d1sp9a1
        complexed with 92u, fe
      2. Domain d5ywha2: 5ywh A:233-434 [362602]
        automated match to d1sp9a2
        complexed with 92u, fe
      3. Domain d5ywhb1: 5ywh B:29-232 [362537]
        automated match to d1sp9a1
        complexed with 92u, fe
      4. Domain d5ywhb2: 5ywh B:233-434 [362538]
        automated match to d1sp9a2
        complexed with 92u, fe
    8. Domains for 5ywi:
      1. Domain d5ywia1: 5ywi A:36-232 [362502]
        automated match to d5dhwa1
        complexed with co, ntd; mutant
      2. Domain d5ywia2: 5ywi A:233-431 [362503]
        automated match to d5dhwa2
        complexed with co, ntd; mutant
    9. Domains for 5ywk:
      1. Domain d5ywka1: 5ywk A:29-232 [362580]
        automated match to d1sp9a1
        complexed with 92x, co
      2. Domain d5ywka2: 5ywk A:233-434 [362581]
        automated match to d1sp9a2
        complexed with 92x, co
      3. Domain d5ywkb1: 5ywk B:29-232 [362607]
        automated match to d1sp9a1
        complexed with 92x, co
      4. Domain d5ywkb2: 5ywk B:233-434 [362608]
        automated match to d1sp9a2
        complexed with 92x, co
    10. Domains for 5yy6:
      1. Domain d5yy6a1: 5yy6 A:35-232 [362545]
        automated match to d5dhwa1
        complexed with 94l, co; mutant
      2. Domain d5yy6a2: 5yy6 A:233-432 [362546]
        automated match to d5dhwa2
        complexed with 94l, co; mutant
    11. Domains for 6isd:
      1. Domain d6isda1: 6isd A:30-232 [360696]
        automated match to d1sp9a1
        complexed with 5bq, co
      2. Domain d6isda2: 6isd A:233-434 [360697]
        automated match to d1sp9a2
        complexed with 5bq, co
      3. Domain d6isdb1: 6isd B:30-232 [360691]
        automated match to d1sp9a1
        complexed with 5bq, co
      4. Domain d6isdb2: 6isd B:233-436 [360692]
        automated match to d1sp9a2
        complexed with 5bq, co
    12. Domains for 6j63:
      1. Domain d6j63a1: 6j63 A:30-232 [364649]
        automated match to d1sp9a1
        complexed with fe, ntd
      2. Domain d6j63a2: 6j63 A:233-434 [364650]
        automated match to d1sp9a2
        complexed with fe, ntd
      3. Domain d6j63b1: 6j63 B:30-232 [364593]
        automated match to d1sp9a1
        complexed with fe, ntd
      4. Domain d6j63b2: 6j63 B:233-434 [364594]
        automated match to d1sp9a2
        complexed with fe, ntd
      5. Domain d6j63c1: 6j63 C:30-232 [364571]
        automated match to d1sp9a1
        complexed with fe, ntd
      6. Domain d6j63c2: 6j63 C:233-434 [364572]
        automated match to d1sp9a2
        complexed with fe, ntd
      7. Domain d6j63d1: 6j63 D:30-232 [364575]
        automated match to d1sp9a1
        complexed with fe, ntd
      8. Domain d6j63d2: 6j63 D:233-434 [364576]
        automated match to d1sp9a2
        complexed with fe, ntd
    13. Domains for 6jx9:
      1. Domain d6jx9a1: 6jx9 A:35-232 [382070]
        automated match to d1sp9a1
        complexed with co, cqc
      2. Domain d6jx9a2: 6jx9 A:233-436 [382071]
        automated match to d1sp9a2
        complexed with co, cqc
    14. Domains for 6lgt:
      1. Domain d6lgta1: 6lgt A:35-232 [390888]
        automated match to d1sp9a1
        complexed with co, ed3, mpd
      2. Domain d6lgta2: 6lgt A:233-437 [390889]
        automated match to d1sp9a2
        complexed with co, ed3, mpd

More info for Protein 4-hydroxyphenylpyruvate dioxygenase, HppD from d.32.1.3: Extradiol dioxygenases

Timeline for Protein 4-hydroxyphenylpyruvate dioxygenase, HppD from d.32.1.3: Extradiol dioxygenases: