Lineage for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2092885Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 protein domains)
    this domain interrupts the other domain which defines family

Protein Domains:

  1. 2092886D-2-hydroxyisocaproate dehydrogenase [51835] (1 species)
  2. 2092889D-glycerate dehydrogenase [51837] (1 species)
  3. 2092893D-lactate dehydrogenase [51841] (1 species)
  4. 2092903Formate dehydrogenase [51831] (1 species)
  5. 2092909L-alanine dehydrogenase [51843] (1 species)
  6. 2092914Nicotinamide nucleotide transhydrogenase dI component [63937] (1 species)
    L-alanine dehydrogenase homologue
  7. 2092956Phosphoglycerate dehydrogenase [51839] (2 species)
    has additional C-terminal domain of the ferredoxin fold
    1. 2092957Species Escherichia coli [TaxId:562] [51840] (7 PDB entries)
    2. 2092977Species Mycobacterium tuberculosis [TaxId:1773] [141927] (2 PDB entries)
      Uniprot P0A544 98-281
  8. 2092982Putative formate dehydrogenase [51833] (1 species)
  9. 2092986S-adenosylhomocystein hydrolase [51845] (3 species)
    1. 2092987Species Human (Homo sapiens) [TaxId:9606] [51846] (3 PDB entries)
    2. 2092993Species Norway rat (Rattus norvegicus) [TaxId:10116] [51847] (7 PDB entries)
    3. 2093030Species Plasmodium falciparum, isolate 3D7 [TaxId:5833] [117431] (1 PDB entry)
      Uniprot P50250
  10. 2093035Transcription corepressor CtbP [82298] (2 species)
    C-terminal binding protein 1; a dehydrogenase
    1. 2093036Species Human (Homo sapiens), Ctbp1 [TaxId:9606] [82299] (4 PDB entries)
    2. 2093041Species Norway rat (Rattus norvegicus), Ctbp3 [TaxId:10116] [89529] (2 PDB entries)

More info for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

Timeline for Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain: