SCOPe 2.08: Protein: S-adenosylhomocystein hydrolase

Lineage for Protein: S-adenosylhomocystein hydrolase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)
Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 proteins)
this domain interrupts the other domain which defines family
Protein S-adenosylhomocystein hydrolase [51845] (3 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51846] (3 PDB entries)
1. Domains for 1a7a:
  1. Domain d1a7aa1: 1a7a A:190-352 [30104]
    Other proteins in same PDB: d1a7aa2, d1a7ab2
    complexed with adc, nad
  2. Domain d1a7ab1: 1a7a B:190-352 [30105]
    Other proteins in same PDB: d1a7aa2, d1a7ab2
    complexed with adc, nad
2. Domain for 1li4:
  - Domain d1li4a1: 1li4 A:190-352 [84616]
    Other proteins in same PDB: d1li4a2
    complexed with ipa, nad, noc
3. Domains for 4yvf:
  1. Domain d4yvfa2: 4yvf A:190-352 [310110]
    Other proteins in same PDB: d4yvfa1, d4yvfb1
    automated match to d1li4a1
    complexed with nai, xfa
  2. Domain d4yvfb2: 4yvf B:190-352 [310112]
    Other proteins in same PDB: d4yvfa1, d4yvfb1
    automated match to d1li4a1
    complexed with nai, xfa
Norway rat (Rattus norvegicus) [TaxId:10116] [51847] (7 PDB entries)
1. Domains for 1b3r:
  1. Domain d1b3ra1: 1b3r A:190-352 [30106]
    Other proteins in same PDB: d1b3ra2, d1b3rb2, d1b3rc2, d1b3rd2
    complexed with nad
  2. Domain d1b3rb1: 1b3r B:190-352 [30107]
    Other proteins in same PDB: d1b3ra2, d1b3rb2, d1b3rc2, d1b3rd2
    complexed with nad
  3. Domain d1b3rc1: 1b3r C:190-352 [30108]
    Other proteins in same PDB: d1b3ra2, d1b3rb2, d1b3rc2, d1b3rd2
    complexed with nad
  4. Domain d1b3rd1: 1b3r D:190-352 [30109]
    Other proteins in same PDB: d1b3ra2, d1b3rb2, d1b3rc2, d1b3rd2
    complexed with nad
2. Domains for 1d4f:
  1. Domain d1d4fa1: 1d4f A:190-352 [30110]
    Other proteins in same PDB: d1d4fa2, d1d4fb2, d1d4fc2, d1d4fd2
    complexed with adn, nad; mutant
  2. Domain d1d4fb1: 1d4f B:190-352 [30111]
    Other proteins in same PDB: d1d4fa2, d1d4fb2, d1d4fc2, d1d4fd2
    complexed with adn, nad; mutant
  3. Domain d1d4fc1: 1d4f C:190-352 [30112]
    Other proteins in same PDB: d1d4fa2, d1d4fb2, d1d4fc2, d1d4fd2
    complexed with adn, nad; mutant
  4. Domain d1d4fd1: 1d4f D:190-352 [30113]
    Other proteins in same PDB: d1d4fa2, d1d4fb2, d1d4fc2, d1d4fd2
    complexed with adn, nad; mutant
3. Domains for 1k0u:
  1. Domain d1k0ua1: 1k0u A:190-352 [67970]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  2. Domain d1k0ub1: 1k0u B:190-352 [67972]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  3. Domain d1k0uc1: 1k0u C:190-352 [67974]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  4. Domain d1k0ud1: 1k0u D:190-352 [67976]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  5. Domain d1k0ue1: 1k0u E:190-352 [67978]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  6. Domain d1k0uf1: 1k0u F:190-352 [67980]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  7. Domain d1k0ug1: 1k0u G:190-352 [67982]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
  8. Domain d1k0uh1: 1k0u H:190-352 [67984]
    Other proteins in same PDB: d1k0ua2, d1k0ub2, d1k0uc2, d1k0ud2, d1k0ue2, d1k0uf2, d1k0ug2, d1k0uh2
    complexed with dea, nad
4. Domains for 1ky4:
  1. Domain d1ky4a1: 1ky4 A:190-352 [77612]
    Other proteins in same PDB: d1ky4a2, d1ky4b2, d1ky4c2, d1ky4d2
    complexed with nad
  2. Domain d1ky4b1: 1ky4 B:1190-1352 [77614]
    Other proteins in same PDB: d1ky4a2, d1ky4b2, d1ky4c2, d1ky4d2
    complexed with nad
  3. Domain d1ky4c1: 1ky4 C:2190-2352 [77616]
    Other proteins in same PDB: d1ky4a2, d1ky4b2, d1ky4c2, d1ky4d2
    complexed with nad
  4. Domain d1ky4d1: 1ky4 D:3190-3352 [77618]
    Other proteins in same PDB: d1ky4a2, d1ky4b2, d1ky4c2, d1ky4d2
    complexed with nad
5. Domains for 1ky5:
  1. Domain d1ky5a1: 1ky5 A:190-352 [77620]
    Other proteins in same PDB: d1ky5a2, d1ky5b2, d1ky5c2, d1ky5d2
    complexed with ady, nai; mutant
  2. Domain d1ky5b1: 1ky5 B:1190-1352 [77622]
    Other proteins in same PDB: d1ky5a2, d1ky5b2, d1ky5c2, d1ky5d2
    complexed with ady, nai; mutant
  3. Domain d1ky5c1: 1ky5 C:2190-2352 [77624]
    Other proteins in same PDB: d1ky5a2, d1ky5b2, d1ky5c2, d1ky5d2
    complexed with ady, nai; mutant
  4. Domain d1ky5d1: 1ky5 D:3190-3352 [77626]
    Other proteins in same PDB: d1ky5a2, d1ky5b2, d1ky5c2, d1ky5d2
    complexed with ady, nai; mutant
6. Domains for 1xwf:
  1. Domain d1xwfa1: 1xwf A:190-352 [122392]
    Other proteins in same PDB: d1xwfa2, d1xwfb2, d1xwfc2, d1xwfd2
    automatically matched to d1d4fa1
    complexed with adn, nad
  2. Domain d1xwfb1: 1xwf B:190-352 [122394]
    Other proteins in same PDB: d1xwfa2, d1xwfb2, d1xwfc2, d1xwfd2
    automatically matched to d1d4fa1
    complexed with adn, nad
  3. Domain d1xwfc1: 1xwf C:190-352 [122396]
    Other proteins in same PDB: d1xwfa2, d1xwfb2, d1xwfc2, d1xwfd2
    automatically matched to d1d4fa1
    complexed with adn, nad
  4. Domain d1xwfd1: 1xwf D:190-352 [122398]
    Other proteins in same PDB: d1xwfa2, d1xwfb2, d1xwfc2, d1xwfd2
    automatically matched to d1d4fa1
    complexed with adn, nad
7. Domains for 2h5l:
  1. Domain d2h5la1: 2h5l A:190-352 [136151]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  2. Domain d2h5lb1: 2h5l B:190-352 [136153]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  3. Domain d2h5lc1: 2h5l C:190-352 [136155]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  4. Domain d2h5ld1: 2h5l D:190-352 [136157]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  5. Domain d2h5le1: 2h5l E:190-352 [136159]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  6. Domain d2h5lf1: 2h5l F:190-352 [136161]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  7. Domain d2h5lg1: 2h5l G:190-352 [136163]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
  8. Domain d2h5lh1: 2h5l H:190-352 [136165]
    Other proteins in same PDB: d2h5la2, d2h5lb2, d2h5lc2, d2h5ld2, d2h5le2, d2h5lf2, d2h5lg2, d2h5lh2
    automated match to d1k0ua1
    complexed with 3dd, nad
Plasmodium falciparum, isolate 3D7 [TaxId:5833] [117431] (1 PDB entry)
Uniprot P50250
- Domains for 1v8b:
  1. Domain d1v8ba1: 1v8b A:235-397 [113564]
    Other proteins in same PDB: d1v8ba2, d1v8bb2, d1v8bc2, d1v8bd2
    complexed with adn, nad
  2. Domain d1v8bb1: 1v8b B:235-397 [113566]
    Other proteins in same PDB: d1v8ba2, d1v8bb2, d1v8bc2, d1v8bd2
    complexed with adn, nad
  3. Domain d1v8bc1: 1v8b C:235-397 [113568]
    Other proteins in same PDB: d1v8ba2, d1v8bb2, d1v8bc2, d1v8bd2
    complexed with adn, nad
  4. Domain d1v8bd1: 1v8b D:235-397 [113570]
    Other proteins in same PDB: d1v8ba2, d1v8bb2, d1v8bc2, d1v8bd2
    complexed with adn, nad

More info for Protein S-adenosylhomocystein hydrolase from c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain

Timeline for Protein S-adenosylhomocystein hydrolase from c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain:

Protein S-adenosylhomocystein hydrolase from c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain first appeared (with stable ids) in SCOP 1.55
Protein S-adenosylhomocystein hydrolase from c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain appears in SCOPe 2.07