SCOP 1.63: Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

Lineage for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

Families:

1. c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain [51736] (6 proteins)
   N-terminal all-beta domain defines family

2. c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (31 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

3. c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (12 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

4. c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 proteins)
   this domain interrupts the other domain which defines family

5. c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain [51848] (4 proteins)

6. c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (10 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

7. c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (8 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

8. c.2.1.8: Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain [51900] (1 protein)

9. c.2.1.9: Potassium channel NAD-binding domain [63944] (4 proteins)

10. c.2.1.11: Bifunctional dehydrogenase/ferrochelatase Met8p, N-terminal domain [75110] (1 protein)

More info for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains

Timeline for Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains:

• Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains first appeared (with stable ids) in SCOP 1.55
  
• Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains appears in SCOP 1.61
  
• Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains appears in SCOP 1.65
  
• Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains appears in the current release, SCOPe 2.08