SCOPe 2.02: Protein: 3-alpha-hydroxysteroid dehydrogenase

Lineage for Protein: 3-alpha-hydroxysteroid dehydrogenase

Root: SCOPe 2.02
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)
Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
Common fold covers whole protein structure
Protein 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

Species:

Human (Homo sapiens), type III [TaxId:9606] [69383] (5 PDB entries)
bile acid binding protein
1. Domains for 1ihi:
  1. Domain d1ihia_: 1ihi A: [66142]
    complexed with iu5, nap
  2. Domain d1ihib_: 1ihi B: [66143]
    complexed with iu5, nap
2. Domains for 1j96:
  1. Domain d1j96a_: 1j96 A: [71616]
    complexed with act, nap, tes
  2. Domain d1j96b_: 1j96 B: [71617]
    complexed with act, nap, tes
3. Domains for 1xjb:
  1. Domain d1xjba_: 1xjb A: [122032]
    automated match to d1j96a_
    complexed with act, bme, cit, edo, nap, so4
  2. Domain d1xjbb_: 1xjb B: [122033]
    automated match to d1j96a_
    complexed with act, bme, cit, edo, nap, so4
4. Domains for 2hdj:
  1. Domain d2hdja_: 2hdj A: [136343]
    automated match to d1j96a_
    complexed with edo, ndp, so4
  2. Domain d2hdjb_: 2hdj B: [136344]
    automated match to d1j96a_
    complexed with edo, ndp, so4
5. Domains for 2ipj:
  1. Domain d2ipja_: 2ipj A: [165634]
    automated match to d1j96a_
    complexed with bme, edo, ffa, nap, so4; mutant
  2. Domain d2ipjb_: 2ipj B: [165635]
    automated match to d1j96a_
    complexed with bme, edo, ffa, nap, so4; mutant
Norway rat (Rattus norvegicus) [TaxId:10116] [51440] (3 PDB entries)
1. Domains for 1afs:
  1. Domain d1afsa_: 1afs A: [28694]
    complexed with nap, tes
  2. Domain d1afsb_: 1afs B: [28695]
    complexed with nap, tes
2. Domains for 1lwi:
  1. Domain d1lwia_: 1lwi A: [28696]
    complexed with nap
  2. Domain d1lwib_: 1lwi B: [28697]
    complexed with nap
3. Domain for 1ral:
  - Domain d1rala_: 1ral A: [28698]

More info for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP)

Timeline for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP):

Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) first appeared (with stable ids) in SCOP 1.55
Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) appears in SCOPe 2.01
Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) appears in SCOPe 2.03
Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) appears in the current release, SCOPe 2.08