SCOPe 2.08: Protein: 3-alpha-hydroxysteroid dehydrogenase

Lineage for Protein: 3-alpha-hydroxysteroid dehydrogenase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)
Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
Common fold covers whole protein structure
Protein 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

Species:

Human (Homo sapiens), type III [TaxId:9606] [69383] (16 PDB entries)
bile acid binding protein
1. Domains for 1ihi:
  1. Domain d1ihia_: 1ihi A: [66142]
    complexed with iu5, nap
  2. Domain d1ihib_: 1ihi B: [66143]
    complexed with iu5, nap
2. Domains for 1j96:
  1. Domain d1j96a1: 1j96 A:2-323 [71616]
    Other proteins in same PDB: d1j96a2, d1j96b2
    complexed with act, nap, tes
  2. Domain d1j96b1: 1j96 B:2-323 [71617]
    Other proteins in same PDB: d1j96a2, d1j96b2
    complexed with act, nap, tes
3. Domains for 1xjb:
  1. Domain d1xjba2: 1xjb A:2-323 [122032]
    Other proteins in same PDB: d1xjba3
    automated match to d1j96a_
    complexed with act, bme, cit, edo, nap, so4
  2. Domain d1xjbb_: 1xjb B: [122033]
    Other proteins in same PDB: d1xjba3
    automated match to d1j96a_
    complexed with act, bme, cit, edo, nap, so4
4. Domains for 2hdj:
  1. Domain d2hdja_: 2hdj A: [136343]
    automated match to d1j96a_
    complexed with edo, ndp, so4
  2. Domain d2hdjb_: 2hdj B: [136344]
    automated match to d1j96a_
    complexed with edo, ndp, so4
5. Domains for 2ipj:
  1. Domain d2ipja_: 2ipj A: [165634]
    automated match to d1j96a_
    complexed with bme, edo, ffa, nap, so4; mutant
  2. Domain d2ipjb_: 2ipj B: [165635]
    automated match to d1j96a_
    complexed with bme, edo, ffa, nap, so4; mutant
6. Domains for 4jq1:
  1. Domain d4jq1a_: 4jq1 A: [252997]
    automated match to d4jqab_
    complexed with edo, nap, nps, po4, tla
  2. Domain d4jq1b_: 4jq1 B: [252998]
    automated match to d4jqab_
    complexed with edo, nap, nps, po4, tla
7. Domains for 4jq2:
  1. Domain d4jq2a_: 4jq2 A: [252999]
    automated match to d4jqab_
    complexed with edo, nap, po4, suz, tla
  2. Domain d4jq2b_: 4jq2 B: [253000]
    automated match to d4jqab_
    complexed with edo, nap, po4, suz, tla
8. Domains for 4jq3:
  1. Domain d4jq3a_: 4jq3 A: [253001]
    automated match to d4jqab_
    complexed with edo, nap, po4, tla, zom
  2. Domain d4jq3b_: 4jq3 B: [253002]
    automated match to d4jqab_
    complexed with edo, nap, po4, tla, zom
9. Domains for 4jq4:
  1. Domain d4jq4a_: 4jq4 A: [253003]
    automated match to d4jqab_
    complexed with edo, imn, nap, po4, tla
  2. Domain d4jq4b_: 4jq4 B: [253004]
    automated match to d4jqab_
    complexed with edo, imn, nap, po4, tla
10. Domains for 4jqa:
  1. Domain d4jqaa_: 4jqa A: [240348]
    automated match to d4jqab_
    complexed with edo, id8, na, nap, po4, tla
  2. Domain d4jqab_: 4jqa B: [238145]
    automated match to d2fgba_
    complexed with edo, id8, na, nap, po4, tla
11. Domains for 4jtq:
  1. Domain d4jtqa_: 4jtq A: [253030]
    automated match to d4jqab_
    complexed with edo, flp, nap, po4, tla
  2. Domain d4jtqb_: 4jtq B: [253031]
    automated match to d4jqab_
    complexed with edo, flp, nap, po4, tla
12. Domains for 4jtr:
  1. Domain d4jtra_: 4jtr A: [253032]
    automated match to d4jqab_
    complexed with edo, ibp, izp, nap, po4, tla
  2. Domain d4jtrb_: 4jtr B: [253033]
    automated match to d4jqab_
    complexed with edo, ibp, izp, nap, po4, tla
13. Domains for 4l1w:
  1. Domain d4l1wa1: 4l1w A:2-323 [256963]
    Other proteins in same PDB: d4l1wa2, d4l1wb2
    automated match to d1xjba_
    complexed with nap, so4, str
  2. Domain d4l1wb1: 4l1w B:2-323 [256964]
    Other proteins in same PDB: d4l1wa2, d4l1wb2
    automated match to d1xjba_
    complexed with nap, so4, str
14. Domains for 4l1x:
  1. Domain d4l1xa1: 4l1x A:2-323 [256965]
    Other proteins in same PDB: d4l1xa2, d4l1xb2
    automated match to d1xjba_
    complexed with nap, so4, str; mutant
  2. Domain d4l1xb1: 4l1x B:2-323 [262898]
    Other proteins in same PDB: d4l1xa2, d4l1xb2
    automated match to d1xjba_
    complexed with nap, so4, str; mutant
15. Domains for 4xo6:
  1. Domain d4xo6a1: 4xo6 A:2-323 [316445]
    Other proteins in same PDB: d4xo6a2, d4xo6b2
    automated match to d2fgba_
    complexed with 5sd, aox, edo, gol, nap, so4
  2. Domain d4xo6b1: 4xo6 B:2-323 [316496]
    Other proteins in same PDB: d4xo6a2, d4xo6b2
    automated match to d2fgba_
    complexed with 5sd, aox, edo, gol, nap, so4
16. Domains for 4xo7:
  1. Domain d4xo7a_: 4xo7 A: [311882]
    automated match to d1ihia_
    complexed with asd, nap, so4
  2. Domain d4xo7b_: 4xo7 B: [311829]
    automated match to d1ihia_
    complexed with asd, nap, so4
Norway rat (Rattus norvegicus) [TaxId:10116] [51440] (3 PDB entries)
1. Domains for 1afs:
  1. Domain d1afsa_: 1afs A: [28694]
    complexed with nap, tes
  2. Domain d1afsb_: 1afs B: [28695]
    complexed with nap, tes
2. Domains for 1lwi:
  1. Domain d1lwia_: 1lwi A: [28696]
    complexed with nap
  2. Domain d1lwib_: 1lwi B: [28697]
    complexed with nap
3. Domain for 1ral:
  - Domain d1rala_: 1ral A: [28698]

More info for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP)

Timeline for Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP):

Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) first appeared (with stable ids) in SCOP 1.55
Protein 3-alpha-hydroxysteroid dehydrogenase from c.1.7.1: Aldo-keto reductases (NADP) appears in SCOPe 2.07