![]() | Class a: All alpha proteins [46456] (289 folds) |
![]() | Fold a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections |
![]() | Superfamily a.26.1: 4-helical cytokines [47266] (4 families) ![]() there are two different topoisomers of this fold with different entanglements of the two crossover connections |
![]() | Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins) contains an additional helix in one of the crossover connections |
![]() | Interferon-alpha 2a [47314] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47315] (9 PDB entries) |
![]() | Interferon-alpha 2b [47312] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47313] (1 PDB entry) |
![]() | Interferon-beta [47309] (2 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47310] (1 PDB entry) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [47311] (4 PDB entries) Uniprot P01575 22-182 CA-atoms only |
![]() | Interferon-gamma [47318] (3 species) intertwined dimer |
![]() | Species Cow (Bos taurus) [TaxId:9913] [47319] (3 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47320] (5 PDB entries) |
![]() | Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47321] (1 PDB entry) |
![]() | Interferon-tau [47316] (1 species) |
![]() | Species Sheep (Ovis aries) [TaxId:9940] [47317] (1 PDB entry) |
![]() | Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species) intertwined dimer, similar to interferon-gamma |
![]() | Species Epstein-Barr virus [TaxId:10376] [47308] (3 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries) |
![]() | Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry) |
![]() | Interleukin-19 [81744] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [81745] (1 PDB entry) |
![]() | Interleukin-22 (IL-22) [89036] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [89037] (5 PDB entries) |
![]() | automated matches [190141] (2 species) not a true protein |
![]() | Species Human (Homo sapiens) [TaxId:9606] [187124] (4 PDB entries) |
![]() | Species Mouse (Mus musculus) [TaxId:10090] [189956] (4 PDB entries) |
Timeline for Family a.26.1.3: Interferons/interleukin-10 (IL-10):