![]() | Class a: All alpha proteins [46456] (289 folds) |
![]() | Fold a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections |
![]() | Superfamily a.26.1: 4-helical cytokines [47266] (4 families) ![]() there are two different topoisomers of this fold with different entanglements of the two crossover connections |
![]() | Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins) contains an additional helix in one of the crossover connections |
![]() | Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species) intertwined dimer, similar to interferon-gamma |
![]() | Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries) |
![]() | Domain d1ilka_: 1ilk A: [16886] |
![]() | Domain d1inra_: 1inr A: [16887] |
![]() | Domain d1j7vl_: 1j7v L: [62704] Other proteins in same PDB: d1j7vr1, d1j7vr2 complexed with IL-10 receptor 1 (IL-10R1) |
![]() | Domain d1y6kl_: 1y6k L: [122662] Other proteins in same PDB: d1y6kr1, d1y6kr2 automated match to d2ilk__ |
![]() | Domain d2ilka_: 2ilk A: [16885] complexed with so4 |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interleukin-10 (cytokine synthesis inhibitory factor, CSIF):