Welcome to SCOPe!

SCOPe (Structural Classification of Proteins — extended) is a database developed at the Berkeley Lab and UC Berkeley to extend the development and maintenance of SCOP. SCOP was conceived at the MRC Laboratory of Molecular Biology, and developed in collaboration with researchers in Berkeley. Work on SCOP (version 1) concluded in June 2009 with the release of SCOP 1.75.

SCOPe classifies many newer structures through a combination of automation and manual curation, and corrects some errors in SCOP, aiming to have the same accuracy as the hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.


  • 2021-04-13: New pdb entries were added in a periodic update; for more info on these updates, see the online documentation.
  • 2019-11-11: We updated the website for PHP7 compatibility. Please let us know of any glitches.
  • 2019-03-05: We added an additional archive of PDB-style coordinate files for domains that were inadvertently omitted from our coordinate file archives.
  • 2018-11-30: We published a paper describing updates to SCOPe, focusing on our findings from classifying large structures. [PDF].
  • 2018-03-02: SCOPe 2.07-stable has been released, with nearly 10,000 new pdb entries added since the last stable release. Click either the About or Stats & History links for more details on what's new!

Classes in SCOPe 2.07:

  1. 2299346a: All alpha proteins [46456] (289 folds)
  2. 2344607b: All beta proteins [48724] (178 folds)
  3. 2413226c: Alpha and beta proteins (a/b) [51349] (148 folds)
  4. 2494617d: Alpha and beta proteins (a+b) [53931] (388 folds)
  5. 2568173e: Multi-domain proteins (alpha and beta) [56572] (71 folds)
  6. 2575216f: Membrane and cell surface proteins and peptides [56835] (60 folds)
  7. 2581248g: Small proteins [56992] (98 folds)
  8. 2590057h: Coiled coil proteins [57942] (7 folds)
  9. 2592940i: Low resolution protein structures [58117] (25 folds)
  10. 2596047j: Peptides [58231] (148 folds)
  11. 2598153k: Designed proteins [58788] (44 folds)
  12. 2598798l: Artifacts [310555] (1 fold)