SCOPe 2.08: Domain d6e4ca1: 6e4c A:1-196

Lineage for d6e4ca1 (6e4c A:1-196)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.52: Restriction endonuclease-like [52979] (4 superfamilies)
   core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest

4. Superfamily c.52.1: Restriction endonuclease-like [52980] (37 families)

5. Family c.52.1.34: PA N-terminal domain [254166] (3 proteins)
   Pfam PF00603; relationship to endonucleases discussed in PubMed 19194458

6. Protein PA N-terminal domain [254375] (8 species)

7. Species Influenza A virus [TaxId:93838] [254808] (91 PDB entries)

8. Domain d6e4ca1: 6e4c A:1-196 [369734]
   Other proteins in same PDB: d6e4ca2
   automated match to d4e5ed_
   complexed with edo, hrj, mn

Details for d6e4ca1

PDB Entry: 6e4c, 2.35 Å

PDB Description: the n-terminal domain of pa endonuclease from the influenza h1n1 virus in complex with 3-hydroxy-6-(2-methyl-4-(5-oxo-4,5-dihydro-1,2,4- oxadiazol-3-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

PDB Compounds: (A:) Polymerase acidic protein

SCOPe Domain Sequences for d6e4ca1:

Sequence, based on SEQRES records:

>d6e4ca1 c.52.1.34 (A:1-196) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdfgsgdpnall
khrfeiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyyl
ekankiksekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfr
qser

Sequence, based on observed residues (ATOM records):

>d6e4ca1 c.52.1.34 (A:1-196) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdfghrfeiieg
rdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankikek
thihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqser

Timeline for d6e4ca1:

• d6e4ca1 first appeared in SCOPe 2.07