Lineage for Superfamily c.52.1: Restriction endonuclease-like

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2459948Fold c.52: Restriction endonuclease-like [52979] (4 superfamilies)
    core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
  4. 2459949Superfamily c.52.1: Restriction endonuclease-like [52980] (37 families) (S)

Families:

  1. 2459950c.52.1.1: Restriction endonuclease EcoRI [52981] (2 protein domains)
    automatically mapped to Pfam PF02963
  2. 2459965c.52.1.2: Restriction endonuclease EcoRV [52984] (1 protein)
    automatically mapped to Pfam PF09233
  3. 2460029c.52.1.3: Restriction endonuclease BamHI [52987] (1 protein)
    automatically mapped to Pfam PF02923
  4. 2460041c.52.1.4: Restriction endonuclease BglI [52990] (1 protein)
  5. 2460045c.52.1.5: Restriction endonuclease BglII [52993] (1 protein)
  6. 2460053c.52.1.6: Restriction endonuclease PvuII [52996] (2 protein domains)
    automatically mapped to Pfam PF09225
  7. 2460081c.52.1.7: Cfr10I/Bse634I [52999] (2 protein domains)
    automatically mapped to Pfam PF07832
  8. 2460101c.52.1.8: Restriction endonuclease MunI [53002] (1 protein)
    automatically mapped to Pfam PF11407
  9. 2460106c.52.1.9: Restriction endonuclease NaeI [53005] (1 protein)
    automatically mapped to Pfam PF09126
  10. 2460113c.52.1.10: Restriction endonuclease NgoIV [53008] (1 protein)
    automatically mapped to Pfam PF09015
  11. 2460120c.52.1.11: Restriction endonuclease BsobI [53011] (1 protein)
    automatically mapped to Pfam PF09194
  12. 2460125c.52.1.12: Restriction endonuclease FokI, C-terminal (catalytic) domain [53014] (1 protein)
    automatically mapped to Pfam PF09254
  13. 2460131c.52.1.13: lambda exonuclease [53017] (1 protein)
  14. 2460143c.52.1.14: DNA mismatch repair protein MutH from [53020] (2 protein domains)
  15. 2460154c.52.1.15: Very short patch repair (VSR) endonuclease [53023] (1 protein)
  16. 2460160c.52.1.16: TnsA endonuclease, N-terminal domain [53026] (1 protein)
  17. 2460167c.52.1.17: Endonuclease I (Holliday junction resolvase) [53029] (2 protein domains)
    automatically mapped to Pfam PF05367
  18. 2460197c.52.1.18: Hjc-like [64080] (3 protein domains)
    Pfam PF01870
  19. 2460224c.52.1.19: Restriction endonuclease HincII [69525] (1 protein)
    automatically mapped to Pfam PF09226
  20. 2460276c.52.1.20: XPF/Rad1/Mus81 nuclease [89716] (3 protein domains)
  21. 2460296c.52.1.21: Restriction endonuclease BstyI [102471] (1 protein)
    automatically mapped to Pfam PF09195
  22. 2460306c.52.1.22: Type II restriction endonuclease catalytic domain [102474] (1 protein)
  23. 2460311c.52.1.23: Restriction endonuclease MspI [110624] (1 protein)
    automatically mapped to Pfam PF09208
  24. 2460318c.52.1.24: Exodeoxyribonuclease V beta chain (RecB), C-terminal domain [117619] (1 protein)
    related to the RecC domain
  25. 2460323c.52.1.25: Exodeoxyribonuclease V beta chain (RecC), C-terminal domain [117622] (1 protein)
    related to the RecB domain
  26. 2460328c.52.1.26: Hypothetical protein VC1899 [117625] (1 protein)
    contains 2 extra N-terminal domains; d1: [alpha/beta; 3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest; topological similarity to the Formyltransferase fold (53327)]; d2: [distorted "winged helix" fold (46785)]
    automatically mapped to Pfam PF09002
  27. 2460332c.52.1.27: Hypothetical protein TT1808 (TTHA1514) [117628] (1 protein)
    Pfam PF05685; DUF820
  28. 2460338c.52.1.28: RecU-like [117631] (2 protein domains)
    Pfam PF03838
  29. 2460355c.52.1.29: Restriction endonuclease EcoO109IR [117635] (1 protein)
  30. 2460362c.52.1.30: MRR-like [117638] (1 protein)
    Pfam PF04471
  31. 2460366c.52.1.31: PA4535-like [142449] (1 protein)
    contains the PD motif at the beginning of strand 2 and putative catalytic glutamate in strand 3, whereas the putative catalytic lysine is migrated to an alpha-helix
    automatically mapped to Pfam PF08682
  32. 2460370c.52.1.32: XisH-like [159601] (1 protein)
    Pfam PF08814
  33. 2460377c.52.1.33: YaeQ-like [159605] (2 protein domains)
    Pfam PF07152; contains extra N- and C-terminal beta-structures forming additional five-stranded beta-sheet; retains the PD motif in the putative active site
  34. 2460385c.52.1.34: PA N-terminal domain [254166] (2 protein domains)
    Pfam PF00603; relationship to endonucleases discussed in PubMed 19194458
  35. 2460484c.52.1.35: Virus-type replication-repair nuclease (VRR-Nuc) [310663] (3 protein domains)
    Pfam PF08774
  36. 2460500c.52.1.36: Splicing factor Prp8 endonuclease-like domain [345968] (1 protein)
    Pfam PF10596
    Likely homology to endonuclease domains discussed in PubMed 21441348, PubMed 23354046
  37. 2460506c.52.1.0: automated matches [191531] (1 protein)
    not a true family

More info for Superfamily c.52.1: Restriction endonuclease-like

Timeline for Superfamily c.52.1: Restriction endonuclease-like: