SCOPe 2.08: Domain d6i4ba1: 6i4b A:158-567

Lineage for d6i4ba1 (6i4b A:158-567)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141759] (3 PDB entries)
   Uniprot Q08210 158-566
   homolog, mitochonrial

8. Domain d6i4ba1: 6i4b A:158-567 [361445]
   Other proteins in same PDB: d6i4ba2, d6i4bb2
   automated match to d1tv5a1
   complexed with e2n, fmn, oro
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d6i4ba1

PDB Entry: 6i4b, 1.98 Å

PDB Description: plasmodium falciparum dihydroorotate dehydrogenase (dhodh) co- crystallized with 3-hydroxy-1-methyl-5-((3-(trifluoromethyl)phenoxy) methyl)-1h-pyrazole-4-carboxylic acid

PDB Compounds: (A:) dihydroorotate dehydrogenase

SCOPe Domain Sequences for d6i4ba1:

Sequence; same for both SEQRES and ATOM records:

>d6i4ba1 c.1.4.1 (A:158-567) Dihydroorotate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
fesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldf
inpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscg
fnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryad
yiainvsspntpglrdnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplvf
vklapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistk
ficemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikreln
hllyqrgyynlkeaigrkhs

Timeline for d6i4ba1:

• d6i4ba1 first appeared in SCOPe 2.07