PDB entry 6i4b

View 6i4b on RCSB PDB site
Description: Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with 3-Hydroxy-1-methyl-5-((3-(trifluoromethyl)phenoxy)methyl)-1H-pyrazole-4-carboxylic acid
Class: oxidoreductase
Keywords: dhodh, plasmodium falciparum dhodh, oxidoreductase
Deposited on 2018-11-09, released 2018-12-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-19, with a file datestamp of 2018-12-14.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: dhod
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54A96 (23-End)
      • expression tag (22)
    Domains in SCOPe 2.08: d6i4ba1, d6i4ba2
  • Chain 'B':
    Compound: dihydroorotate dehydrogenase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: dhod
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54A96 (23-End)
      • expression tag (22)
    Domains in SCOPe 2.08: d6i4bb1, d6i4bb2
  • Heterogens: E2N, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i4bA (A:)
mhhhhhhssgvdlgtenlyfqsmfesynpefflydiflkfclkyidgeichdlflllgky
nilpydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprg
qtgnakprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigk
nkdtvnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnl
eknnimndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqin
diksfenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasv
cqlysclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6i4bA (A:)
mfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhld
finpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinsc
gfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigrya
dyiainvsspntpglrdnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplv
fvklapdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdist
kficemynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrel
nhllyqrgyynlkeaigrkhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6i4bB (B:)
mhhhhhhssgvdlgtenlyfqsmfesynpefflydiflkfclkyidgeichdlflllgky
nilpydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprg
qtgnakprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigk
nkdtvnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnl
eknnimndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqin
diksfenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasv
cqlysclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >6i4bB (B:)
mfesynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhld
finpfgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinsc
gfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigrya
dyiainvsspntpglrdnqeagklkniilsvkeeidnleknlwfnttkkkplvfvklapd
lnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemy
nytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqr
gyynlkeaigrkhs