SCOPe 2.08: Domain d6gpjc_: 6gpj C:

Lineage for d6gpjc_ (6gpj C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102135] (7 PDB entries)

8. Domain d6gpjc_: 6gpj C: [354946]
   Other proteins in same PDB: d6gpjd2
   automated match to d1t2aa_
   complexed with cit, edo, g4f, nap
   has additional subdomain(s) that are not in the common domain

Details for d6gpjc_

PDB Entry: 6gpj, 1.94 Å

PDB Description: crystal structure of human gdp-d-mannose 4,6-dehydratase in complex with gdp-4f-man

PDB Compounds: (C:) GDP-mannose 4,6 dehydratase

SCOPe Domain Sequences for d6gpjc_:

Sequence, based on SEQRES records:

>d6gpjc_ c.2.1.2 (C:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens) [TaxId: 9606]}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlyknpqahiegnmkl
hygdltdstclvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktc
glinsvkfyqastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfav
ngilfnhesprrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlm
lqndepedfviatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlk
yyrptevdflqgdctkakqklnwkprvafdelvremvhadvelmrtnpna

Sequence, based on observed residues (ATOM records):

>d6gpjc_ c.2.1.2 (C:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens) [TaxId: 9606]}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlynmklhygdltdst
clvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktcglinsvkfy
qastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfavngilfnhes
prrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlmlqndepedf
viatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlkyyrptevdf
lqgdctkakqklnwkprvafdelvremvhadvelmrtnpna

Timeline for d6gpjc_:

• d6gpjc_ first appeared in SCOPe 2.07