Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

    has additional subdomain(s) that are not in the common domain
  6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)
  7. Species Human (Homo sapiens) [TaxId:9606] [102135] (7 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1t2a:
    1. Domain d1t2aa_: 1t2a A: [99078]
      complexed with gdp, ndp
      has additional subdomain(s) that are not in the common domain
    2. Domain d1t2ab_: 1t2a B: [99079]
      complexed with gdp, ndp
      has additional subdomain(s) that are not in the common domain
    3. Domain d1t2ac_: 1t2a C: [99080]
      complexed with gdp, ndp
      has additional subdomain(s) that are not in the common domain
    4. Domain d1t2ad_: 1t2a D: [99081]
      complexed with gdp, ndp
      has additional subdomain(s) that are not in the common domain
  2. Domain(s) for 5in4:
    1. Domain d5in4a1: 5in4 A:23-372 [321379]
      Other proteins in same PDB: d5in4a2, d5in4b2, d5in4c2, d5in4d2
      automated match to d1t2aa_
      complexed with 6ck, gdp, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d5in4b1: 5in4 B:23-372 [321323]
      Other proteins in same PDB: d5in4a2, d5in4b2, d5in4c2, d5in4d2
      automated match to d1t2aa_
      complexed with 6ck, gdp, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d5in4c1: 5in4 C:23-372 [321313]
      Other proteins in same PDB: d5in4a2, d5in4b2, d5in4c2, d5in4d2
      automated match to d1t2aa_
      complexed with 6ck, gdp, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d5in4d1: 5in4 D:23-372 [321315]
      Other proteins in same PDB: d5in4a2, d5in4b2, d5in4c2, d5in4d2
      automated match to d1t2aa_
      complexed with 6ck, gdp, nap

      has additional subdomain(s) that are not in the common domain
  3. Domain(s) for 5in5:
    1. Domain d5in5a1: 5in5 A:23-372 [321408]
      Other proteins in same PDB: d5in5a2, d5in5b2, d5in5c2, d5in5d2
      automated match to d1t2aa_
      complexed with gdp, gfb, gol, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d5in5b1: 5in5 B:23-372 [321344]
      Other proteins in same PDB: d5in5a2, d5in5b2, d5in5c2, d5in5d2
      automated match to d1t2aa_
      complexed with gdp, gfb, gol, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d5in5c1: 5in5 C:23-372 [321327]
      Other proteins in same PDB: d5in5a2, d5in5b2, d5in5c2, d5in5d2
      automated match to d1t2aa_
      complexed with gdp, gfb, gol, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d5in5d1: 5in5 D:23-372 [321436]
      Other proteins in same PDB: d5in5a2, d5in5b2, d5in5c2, d5in5d2
      automated match to d1t2aa_
      complexed with gdp, gfb, gol, nap

      has additional subdomain(s) that are not in the common domain
  4. Domain(s) for 6gpj:
    1. Domain d6gpja_: 6gpj A: [354951]
      Other proteins in same PDB: d6gpjd2
      automated match to d1t2aa_
      complexed with cit, edo, g4f, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d6gpjb_: 6gpj B: [354974]
      Other proteins in same PDB: d6gpjd2
      automated match to d1t2aa_
      complexed with cit, edo, g4f, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d6gpjc_: 6gpj C: [354946]
      Other proteins in same PDB: d6gpjd2
      automated match to d1t2aa_
      complexed with cit, edo, g4f, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d6gpjd1: 6gpj D:23-372 [354976]
      Other proteins in same PDB: d6gpjd2
      automated match to d1t2aa_
      complexed with cit, edo, g4f, nap

      has additional subdomain(s) that are not in the common domain
  5. Domain(s) for 6gpk:
    1. Domain d6gpka_: 6gpk A: [354959]
      automated match to d1t2aa_
      complexed with edo, gdd, gol, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d6gpkb_: 6gpk B: [354953]
      automated match to d1t2aa_
      complexed with edo, gdd, gol, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d6gpkc_: 6gpk C: [354978]
      automated match to d1t2aa_
      complexed with edo, gdd, gol, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d6gpkd_: 6gpk D: [354952]
      automated match to d1t2aa_
      complexed with edo, gdd, gol, nap

      has additional subdomain(s) that are not in the common domain
  6. Domain(s) for 6gpl:
    1. Domain d6gplb_: 6gpl B: [354955]
      automated match to d1t2aa_
      complexed with bcn, edo, f7e, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d6gplc_: 6gpl C: [354944]
      automated match to d1t2aa_
      complexed with bcn, edo, f7e, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d6gpld_: 6gpl D: [354954]
      automated match to d1t2aa_
      complexed with bcn, edo, f7e, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d6gple_: 6gpl E: [354969]
      automated match to d1t2aa_
      complexed with bcn, edo, f7e, nap

      has additional subdomain(s) that are not in the common domain
  7. Domain(s) for 6q94:
    1. Domain d6q94a_: 6q94 A: [368286]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    2. Domain d6q94b_: 6q94 B: [368279]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    3. Domain d6q94c_: 6q94 C: [368246]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    4. Domain d6q94d_: 6q94 D: [368284]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    5. Domain d6q94e_: 6q94 E: [368281]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    6. Domain d6q94f_: 6q94 F: [368247]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    7. Domain d6q94g_: 6q94 G: [368252]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain
    8. Domain d6q94h_: 6q94 H: [368248]
      automated match to d1t2aa_
      complexed with edo, gdd, nap

      has additional subdomain(s) that are not in the common domain

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 GDP-mannose 4,6-dehydratase

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 GDP-mannose 4,6-dehydratase: