Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like |
Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) binds cofactor molecules in the opposite direction than classical Rossmann fold |
Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins) silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain |
Protein NAD-dependent deacetylase sirtuin-5 [142128] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [142129] (2 PDB entries) Uniprot Q9NXA8 36-302 |
Domain d2b4ya1: 2b4y A:36-302 [127868] complexed with apr, epe, zn |
Domain d2b4yb_: 2b4y B: [127869] automated match to d2b4ya1 complexed with apr, epe, zn |
Domain d2b4yc_: 2b4y C: [127870] automated match to d2b4ya1 complexed with apr, epe, zn |
Domain d2b4yd_: 2b4y D: [127871] automated match to d2b4ya1 complexed with apr, epe, zn |
Domain d2nyra_: 2nyr A: [138827] automated match to d2b4ya1 complexed with svr, zn |
Domain d2nyrb_: 2nyr B: [138828] automated match to d2b4ya1 complexed with svr, zn |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.31.1.5 NAD-dependent deacetylase sirtuin-5: