Welcome to SCOPe!

SCOPe (Structural Classification of Proteins — extended) is a database developed at the Berkeley Lab and UC Berkeley to extend the development and maintenance of SCOP. SCOP was conceived at the MRC Laboratory of Molecular Biology, and developed in collaboration with researchers in Berkeley. Work on SCOP (version 1) concluded in June 2009 with the release of SCOP 1.75.

SCOPe classifies many newer structures through a combination of automation and manual curation, and corrects some errors in SCOP, aiming to have the same accuracy as the hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.


  • 2017-12-22: SCOPe 2.07-stable is being prepared for release in Feb 2018. The new release features manual classification of domains from many larger structures, including the spliceosome, proteasome, and RNA polymerase I, and many other Pfam families not previously classified in SCOP. We have identified dozens of new superfamilies that will be included in the upcoming release.
  • 2014-12-18: New pdb entries were added in a periodic update; for more info on these updates, see the online documentation.
  • 2017-09-01: We are still without funding, but shutdown has been postponed for a year. More details are here.
  • 2016-11-30: We published a paper on new features in SCOPe [PDF].
  • 2015-09-22: We published a paper about how SCOP and SCOPe have been used in recent studies [PDF].

Classes in SCOPe 2.04:

  1. 1473060a: All alpha proteins [46456] (285 folds)
  2. 1510239b: All beta proteins [48724] (176 folds)
  3. 1565955c: Alpha and beta proteins (a/b) [51349] (148 folds)
  4. 1631855d: Alpha and beta proteins (a+b) [53931] (380 folds)
  5. 1689992e: Multi-domain proteins (alpha and beta) [56572] (68 folds)
  6. 1695624f: Membrane and cell surface proteins and peptides [56835] (57 folds)
  7. 1700111g: Small proteins [56992] (91 folds)
  8. 1708126h: Coiled coil proteins [57942] (7 folds)
  9. 1710350i: Low resolution protein structures [58117] (25 folds)
  10. 1713148j: Peptides [58231] (126 folds)
  11. 1715088k: Designed proteins [58788] (44 folds)