SCOPe 2.08: Domain d2afub_: 2afu B:

Lineage for d2afub_ (2afu B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
   part of Pfam PF04389

6. Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
   Glutaminyl cyclase

7. Species Human (Homo sapiens) [TaxId:9606] [142534] (29 PDB entries)
   Uniprot Q16769 33-361

8. Domain d2afub_: 2afu B: [126706]
   automated match to d2afma1
   complexed with bgt, zn

Details for d2afub_

PDB Entry: 2afu, 2.22 Å

PDB Description: crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester

PDB Compounds: (B:) Glutaminyl-peptide cyclotransferase

SCOPe Domain Sequences for d2afub_:

Sequence, based on SEQRES records:

>d2afub_ c.56.5.8 (B:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgqeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

Sequence, based on observed residues (ATOM records):

>d2afub_ c.56.5.8 (B:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllsldlslqliffdgqeaflhwspqdslygsrhla
akmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehelhe
lgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneenld
estidnlnkilqvfvleylhl

Timeline for d2afub_:

• d2afub_ first appeared in SCOP 1.73, called d2afub1
  
• d2afub_ appears in SCOPe 2.07