PDB entry 2afu

View 2afu on RCSB PDB site
Description: Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester
Class: transferase
Keywords: alpha-beta protein, metalloprotein, TRANSFERASE
Deposited on 2005-07-26, released 2005-08-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: 0.188
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-328)
      • engineered (168)
    Domains in SCOPe 2.08: d2afua1
  • Chain 'B':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-328)
      • engineered (168)
    Domains in SCOPe 2.08: d2afub_
  • Heterogens: ZN, BGT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2afuA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgqeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2afuA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllsldlslqliffdgqeaflhwspqdslygsrhla
akmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehelhe
lgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneenld
estidnlnkilqvfvleylhl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2afuB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgqeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2afuB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllsldlslqliffdgqeaflhwspqdslygsrhla
akmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehelhe
lgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneenld
estidnlnkilqvfvleylhl