SCOPe 2.08: Domain d1t2kb_: 1t2k B:

Lineage for d1t2kb_ (1t2k B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.5: 'Winged helix' DNA-binding domain [46785] (86 families)
   contains a small beta-sheet (wing)

5. Family a.4.5.23: Interferon regulatory factor [46877] (4 proteins)
   Pfam PF00605

6. Protein Interferon regulatory factor 3, IRF-3 [116791] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [116792] (3 PDB entries)
   Uniprot Q14653 3-112

8. Domain d1t2kb_: 1t2k B: [112221]
   Other proteins in same PDB: d1t2kc1, d1t2kc2, d1t2kd_
   protein/DNA complex

Details for d1t2kb_

PDB Entry: 1t2k, 3 Å

PDB Description: structure of the dna binding domains of irf3, atf-2 and jun bound to dna

PDB Compounds: (B:) Interferon regulatory factor 3

SCOPe Domain Sequences for d1t2kb_:

Sequence; same for both SEQRES and ATOM records:

>d1t2kb_ a.4.5.23 (B:) Interferon regulatory factor 3, IRF-3 {Human (Homo sapiens) [TaxId: 9606]}
pkprilpwlvsqldlgqlegvawvnksrtrfripwkhglrqdaqqedfgifqawaeatga
yvpgrdkpdlptwkrnfrsalnrkeglrlaedrskdphdphkiyefvn

Timeline for d1t2kb_:

• d1t2kb_ first appeared in SCOP 1.71
  
• d1t2kb_ appears in SCOPe 2.07