SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family a.4.5.23: Interferon regulatory factor

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1981147Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. 1982196Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (85 families) (S)
    contains a small beta-sheet (wing)
  5. 1982743Family a.4.5.23: Interferon regulatory factor [46877] (4 protein domains)
    Pfam PF00605

Protein Domains:

  1. 1982744Interferon regulatory factor 1 (IRF-1) [46878] (1 species)
  2. 1982748Interferon regulatory factor 3, IRF-3 [116791] (1 species)
  3. 1982760Interferon regulatory factor-2, IRF-2 [46880] (1 species)
  4. 1982770automated matches [191301] (1 species)
    not a true protein

More info for Family a.4.5.23: Interferon regulatory factor

Timeline for Family a.4.5.23: Interferon regulatory factor: