Lineage for d1x86e2 (1x86 E:1020-1133)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2394380Fold b.55: PH domain-like barrel [50728] (3 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2394381Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2394382Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
    Pfam PF00169
  6. 2394565Protein Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  7. 2394566Species Human (Homo sapiens), gamma isoform [TaxId:9606] [110271] (2 PDB entries)
    Uniprot Q9NZN5 766-1138
  8. 2394570Domain d1x86e2: 1x86 E:1020-1133 [109511]
    Other proteins in same PDB: d1x86a1, d1x86b_, d1x86c1, d1x86d_, d1x86e1, d1x86f_, d1x86g1, d1x86h_
    complexed with po4

Details for d1x86e2

PDB Entry: 1x86 (more details), 3.22 Å

PDB Description: Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
PDB Compounds: (E:) Rho guanine nucleotide exchange factor 12

SCOPe Domain Sequences for d1x86e2:

Sequence, based on SEQRES records: (download)

>d1x86e2 b.55.1.1 (E:1020-1133) Rho guanine nucleotide exchange factor 12 {Human (Homo sapiens), gamma isoform [TaxId: 9606]}
mihegplvwkvnrdktidlytllledilvllqkqddrlvlrchskilastadskhtfspv
iklstvlvrqvatdnkalfvismsdngaqiyelvaqtvsektvwqdlicrmaas

Sequence, based on observed residues (ATOM records): (download)

>d1x86e2 b.55.1.1 (E:1020-1133) Rho guanine nucleotide exchange factor 12 {Human (Homo sapiens), gamma isoform [TaxId: 9606]}
mihegplvwkvnrdktidlytllledilvllqkqddrlvspviklstvlvrqvnkalfvi
sqiyelvaqtvsektvwqdlicrmaas

SCOPe Domain Coordinates for d1x86e2:

Click to download the PDB-style file with coordinates for d1x86e2.
(The format of our PDB-style files is described here.)

Timeline for d1x86e2: