Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2061576Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2061577Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2061578Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 protein domains)
    Pfam PF00169

Protein Domains:

  1. 20615793-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 2061587Alpha-1-syntrophin [141411] (1 species)
  3. 2061590beta-spectrin [50733] (3 species)
    1. 2061591Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 2061593Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 2061595Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 2061598Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 2061606Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 2061609Centaurin-delta 1 [141395] (1 species)
  7. 2061612Cytohesin 2 [141401] (1 species)
  8. 2061616Cytohesin 3 [141397] (1 species)
  9. 2061619Dbl's big sister, Dbs [74989] (1 species)
    • 2061620Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 2061633DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 2061636Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 2061639Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 2061643Dynamin [50736] (1 species)
  14. 2061649Exocyst complex protein EXO84 [141399] (1 species)
  15. 2061652FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 2061655FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 2061658G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 2061659Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries)
    2. 2061669Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 2061671GEF of intersectin [74991] (1 species)
  19. 2061675GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 2061681Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 2061693KIAA1914 [141407] (1 species)
  22. 2061696Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 2061699Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 2061702Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 2061706Phospholipase C delta-1 [50731] (1 species)
  26. 2061709Phospholipase C-beta-2 [159207] (1 species)
  27. 2061713Pleckstrin [50740] (1 species)
  28. 2061723Pleckstrin-2 [141409] (1 species)
  29. 2061726Protein kinase c, d2 type [141419] (1 species)
  30. 2061729Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 2061735Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 2061738Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 2061741Rho GTPase-activating protein 21 [159213] (1 species)
  34. 2061749Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 2061757Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 2061764Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 2061768Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 2061771SET binding factor 1, Sbf1 [110260] (1 species)
  39. 2061774SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 2061777Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 2061780Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 2061781Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 2061788Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 2061790Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 2061796Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 2061807Tapp1 [74993] (1 species)
  45. 2061810Tapp2 [110258] (1 species)
  46. 2061813Triple functional domain protein TRIO [110264] (1 species)
  47. 2061817UNC-89 [50753] (1 species)
  48. 2061820automated matches [190063] (3 species)
    not a true protein
    1. 2061821Species Cow (Bos taurus) [TaxId:9913] [270894] (1 PDB entry)
    2. 2061826Species Human (Homo sapiens) [TaxId:9606] [187187] (8 PDB entries)
    3. 2061845Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):