Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2394380Fold b.55: PH domain-like barrel [50728] (3 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2394381Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2394382Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 protein domains)
    Pfam PF00169

Protein Domains:

  1. 23943833-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 2394391Alpha-1-syntrophin [141411] (1 species)
  3. 2394394beta-spectrin [50733] (3 species)
    1. 2394395Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 2394397Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 2394399Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 2394402Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 2394410Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 2394413Centaurin-delta 1 [141395] (1 species)
  7. 2394416Cytohesin 2 [141401] (1 species)
  8. 2394420Cytohesin 3 [141397] (1 species)
  9. 2394423Dbl's big sister, Dbs [74989] (1 species)
    • 2394424Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 2394437DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 2394440Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 2394443Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 2394447Dynamin [50736] (1 species)
  14. 2394453Exocyst complex protein EXO84 [141399] (1 species)
  15. 2394456FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 2394459FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 2394462G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 2394463Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries)
    2. 2394473Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 2394475GEF of intersectin [74991] (1 species)
  19. 2394479GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 2394485Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 2394497KIAA1914 [141407] (1 species)
  22. 2394500Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 2394503Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 2394506Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 2394510Phospholipase C delta-1 [50731] (1 species)
  26. 2394513Phospholipase C-beta-2 [159207] (1 species)
  27. 2394517Pleckstrin [50740] (1 species)
  28. 2394527Pleckstrin-2 [141409] (1 species)
  29. 2394530Protein kinase c, d2 type [141419] (1 species)
  30. 2394533Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 2394539Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 2394542Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 2394545Rho GTPase-activating protein 21 [159213] (1 species)
  34. 2394553Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 2394565Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 2394572Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 2394576Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 2394579SET binding factor 1, Sbf1 [110260] (1 species)
  39. 2394582SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 2394585Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 2394588Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 2394589Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 2394596Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 2394598Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 2394604Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 2394615Tapp1 [74993] (1 species)
  45. 2394618Tapp2 [110258] (1 species)
  46. 2394621Triple functional domain protein TRIO [110264] (1 species)
  47. 2394625UNC-89 [50753] (1 species)
  48. 2394628automated matches [190063] (3 species)
    not a true protein
    1. 2394629Species Cow (Bos taurus) [TaxId:9913] [270894] (1 PDB entry)
    2. 2394634Species Human (Homo sapiens) [TaxId:9606] [187187] (8 PDB entries)
    3. 2394653Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):