PDB entry 6tmh

View 6tmh on RCSB PDB site
Description: Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, OSCP/F1/c-ring model
Class: membrane protein
Keywords: mitochondrial, ATP synthase, F1, c-ring, MEMBRANE PROTEIN
Deposited on 2019-12-04, released 2020-12-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP synthase subunit alpha,subunit alpha
    Species: Toxoplasma gondii GT1 [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
    • Uniprot S7UU80 (Start-537)
    • PDB 6TMH (538-End)
    Domains in SCOPe 2.07: d6tmha1, d6tmha2, d6tmha3
  • Chain 'B':
    Compound: ATP synthase subunit beta
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6tmhb1, d6tmhb2, d6tmhb3
  • Chain 'C':
    Compound: ATP synthase subunit alpha,subunit alpha
    Species: Toxoplasma gondii GT1 [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
    • Uniprot S7UU80 (Start-537)
    • PDB 6TMH (538-End)
    Domains in SCOPe 2.07: d6tmhc1, d6tmhc2, d6tmhc3
  • Chain 'D':
    Compound: ATP synthase subunit beta
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6tmhd1, d6tmhd2, d6tmhd3
  • Chain 'E':
    Compound: ATP synthase subunit alpha,subunit alpha
    Species: Toxoplasma gondii GT1 [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
    • Uniprot S7UU80 (Start-537)
    • PDB 6TMH (538-End)
    Domains in SCOPe 2.07: d6tmhe1, d6tmhe2, d6tmhe3
  • Chain 'F':
    Compound: ATP synthase subunit beta
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6tmhf1, d6tmhf2, d6tmhf3
  • Chain 'G':
    Compound: oligomycin sensitivity conferring protein (OSCP)
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: subunit c
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'd':
    Compound: ATP synthase subunit delta
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'e':
    Compound: ATP synthase subunit epsilon
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Chain 'g':
    Compound: ATP synthase subunit gamma
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6tmhg_
  • Chain 'i':
    Compound: Inhibitor of F1
    Species: Toxoplasma gondii (strain ATCC 50853 / GT1) [TaxId:507601]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ADP, ATP, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tmhA (A:)
mtihsclarravsvaasgarafasglgaravavgalqsarllhtsslraagakispsems
rlleeriagwktqtsteevgrvvsvgdgiarlfglegvqagelvefqngmtgmalnletd
nvgvvifgddrsvlegdsvkrtgrivdvpigpgllgrvvdalgnpidgkgpipakerrrv
elkapgiiprksvhepmmtglkcvdalvpvgrgqreliigdrqtgktavavdaiinqkei
ndstddeskklyciyvavgqkrstvaqivkaleqrdamkyttvvaataseaaplqflapy
sgcamgewfrdsgrhcviiyddlskqatayrqmslllrrppgreaypgdvfylhsrller
aakmgdksgggsltalpvietqagdvsayiptnvisitdgqifletelfykgirpainvg
lsvsrvgsaaqvkamkqvagtmklelaqyrevaafaqfgsdldastrqlltrgtaltell
kqrqyspmknsvqvcvlycgvkgyldpldpkeisrfeslfidyinanhqdilktieteke
lsekteaklraavdefvamnefkkk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhA (A:)
kispsemsrlleeriagwktqtsteevgrvvsvgdgiarlfglegvqagelvefqngmtg
malnletdnvgvvifgddrsvlegdsvkrtgrivdvpigpgllgrvvdalgnpidgkgpi
pakerrrvelkapgiiprksvhepmmtglkcvdalvpvgrgqreliigdrqtgktavavd
aiinqkeindstddeskklyciyvavgqkrstvaqivkaleqrdamkyttvvaataseaa
plqflapysgcamgewfrdsgrhcviiyddlskqatayrqmslllrrppgreaypgdvfy
lhsrlleraakmgdksgggsltalpvietqagdvsayiptnvisitdgqifletelfykg
irpainvglsvsrvgsaaqvkamkqvagtmklelaqyrevaafaqfgsdldastrqlltr
gtaltellkqrqyspmknsvqvcvlycgvkgyldpldpkeisrfeslfidyinanhqdil
ktietekelsekteaklraavdefvamnefkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tmhB (B:)
maspalqtcwrnlarlsgaqvrpshfgafslgsrmspfssllgaraspiatgraglrfls
saapnpgkkpasaappagtnhgritqvigavvdvhfdeqlppilnslevqghtnrlvlev
aqhlgentvrtiamdateglvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvp
akktysihraaplfadqstepgllqtgikvvdllapyakggkiglfggagvgktvlimel
innvankhggfsvfagvgertregndlyhemmttgvikrkkledgkfdftgskaalvygq
mneppgararvaltalsvaeyfrdeqgqdvllfidniyrftqagsevsallgripsavgy
qptlatdlgqlqeritttkkgsitsvqavyvpaddltdpapattfahldattvlsrqiae
lgiypavdpldstsrmlapeivgqehydtaratqkllqdykslqdiiailgmdelseedk
lvvsrarkiqrflsqpftvaevftgkpgrfvelpetiksaqtilrgecddlpemafymcg
gleevrskavkmaqeaasgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhB (B:)
tnhgritqvigavvdvhfdeqlppilnslevqghtnrlvlevaqhlgentvrtiamdate
glvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvpakktysihraaplfadqs
tepgllqtgikvvdllapyakggkiglfggagvgktvlimelinnvankhggfsvfagvg
ertregndlyhemmttgvikrkkledgkfdftgskaalvygqmneppgararvaltalsv
aeyfrdeqgqdvllfidniyrftqagsevsallgripsavgyqptlatdlgqlqerittt
kkgsitsvqavyvpaddltdpapattfahldattvlsrqiaelgiypavdpldstsrmla
peivgqehydtaratqkllqdykslqdiiailgmdelseedklvvsrarkiqrflsqpft
vaevftgkpgrfvelpetiksaqtilrgecddlpemafymcggleevrskavkmaqeaa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tmhC (C:)
mtihsclarravsvaasgarafasglgaravavgalqsarllhtsslraagakispsems
rlleeriagwktqtsteevgrvvsvgdgiarlfglegvqagelvefqngmtgmalnletd
nvgvvifgddrsvlegdsvkrtgrivdvpigpgllgrvvdalgnpidgkgpipakerrrv
elkapgiiprksvhepmmtglkcvdalvpvgrgqreliigdrqtgktavavdaiinqkei
ndstddeskklyciyvavgqkrstvaqivkaleqrdamkyttvvaataseaaplqflapy
sgcamgewfrdsgrhcviiyddlskqatayrqmslllrrppgreaypgdvfylhsrller
aakmgdksgggsltalpvietqagdvsayiptnvisitdgqifletelfykgirpainvg
lsvsrvgsaaqvkamkqvagtmklelaqyrevaafaqfgsdldastrqlltrgtaltell
kqrqyspmknsvqvcvlycgvkgyldpldpkeisrfeslfidyinanhqdilktieteke
lsekteaklraavdefvamnefkkk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhC (C:)
evgrvvsvgdgiarlfglegvqagelvefqngmtgmalnletdnvgvvifgddrsvlegd
svkrtgrivdvpigpgllgrvvdalgnpidgkgpipakerrrvelkapgiiprksvhepm
mtglkcvdalvpvgrgqreliigdrqtgktavavdaiinqkeindstddeskklyciyva
vgqkrstvaqivkaleqrdamkyttvvaataseaaplqflapysgcamgewfrdsgrhcv
iiyddlskqatayrqmslllrrppgreaypgdvfylhsrlleraakmgdksgggsltalp
vietqagdvsayiptnvisitdgqifletelfykgirpainvglsvsrvgsaaqvkamkq
vagtmklelaqyrevaafaqfgsdldastrqlltrgtaltellkqrqyspmknsvqvcvl
ycgvkgyldpldpkeisrfeslfidyinanhqdilktietekelsekteaklraavdefv
amnefkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6tmhD (D:)
maspalqtcwrnlarlsgaqvrpshfgafslgsrmspfssllgaraspiatgraglrfls
saapnpgkkpasaappagtnhgritqvigavvdvhfdeqlppilnslevqghtnrlvlev
aqhlgentvrtiamdateglvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvp
akktysihraaplfadqstepgllqtgikvvdllapyakggkiglfggagvgktvlimel
innvankhggfsvfagvgertregndlyhemmttgvikrkkledgkfdftgskaalvygq
mneppgararvaltalsvaeyfrdeqgqdvllfidniyrftqagsevsallgripsavgy
qptlatdlgqlqeritttkkgsitsvqavyvpaddltdpapattfahldattvlsrqiae
lgiypavdpldstsrmlapeivgqehydtaratqkllqdykslqdiiailgmdelseedk
lvvsrarkiqrflsqpftvaevftgkpgrfvelpetiksaqtilrgecddlpemafymcg
gleevrskavkmaqeaasgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhD (D:)
nhgritqvigavvdvhfdeqlppilnslevqghtnrlvlevaqhlgentvrtiamdateg
lvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvpakktysihraaplfadqst
epgllqtgikvvdllapyakggkiglfggagvgktvlimelinnvankhggfsvfagvge
rtregndlyhemmttgvikrkkledgkfdftgskaalvygqmneppgararvaltalsva
eyfrdeqgqdvllfidniyrftqagsevsallgripsavgyqptlatdlgqlqeritttk
kgsitsvqavyvpaddltdpapattfahldattvlsrqiaelgiypavdpldstsrmlap
eivgqehydtaratqkllqdykslqdiiailgmdelseedklvvsrarkiqrflsqpftv
aevftgkpgrfvelpetiksaqtilrgecddlpemafymcggleevrskavkmaq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6tmhE (E:)
mtihsclarravsvaasgarafasglgaravavgalqsarllhtsslraagakispsems
rlleeriagwktqtsteevgrvvsvgdgiarlfglegvqagelvefqngmtgmalnletd
nvgvvifgddrsvlegdsvkrtgrivdvpigpgllgrvvdalgnpidgkgpipakerrrv
elkapgiiprksvhepmmtglkcvdalvpvgrgqreliigdrqtgktavavdaiinqkei
ndstddeskklyciyvavgqkrstvaqivkaleqrdamkyttvvaataseaaplqflapy
sgcamgewfrdsgrhcviiyddlskqatayrqmslllrrppgreaypgdvfylhsrller
aakmgdksgggsltalpvietqagdvsayiptnvisitdgqifletelfykgirpainvg
lsvsrvgsaaqvkamkqvagtmklelaqyrevaafaqfgsdldastrqlltrgtaltell
kqrqyspmknsvqvcvlycgvkgyldpldpkeisrfeslfidyinanhqdilktieteke
lsekteaklraavdefvamnefkkk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhE (E:)
emsrlleeriagwktqtsteevgrvvsvgdgiarlfglegvqagelvefqngmtgmalnl
etdnvgvvifgddrsvlegdsvkrtgrivdvpigpgllgrvvdalgnpidgkgpipaker
rrvelkapgiiprksvhepmmtglkcvdalvpvgrgqreliigdrqtgktavavdaiinq
keindstddeskklyciyvavgqkrstvaqivkaleqrdamkyttvvaataseaaplqfl
apysgcamgewfrdsgrhcviiyddlskqatayrqmslllrrppgreaypgdvfylhsrl
leraakmgdksgggsltalpvietqagdvsayiptnvisitdgqifletelfykgirpai
nvglsvsrvgsaaqvkamkqvagtmklelaqyrevaafaqfgsdldastrqlltrgtalt
ellkqrqyspmknsvqvcvlycgvkgyldpldpkeisrfeslfidyinanhqdilktiet
ekelsekteaklraavdefvamnefkk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6tmhF (F:)
maspalqtcwrnlarlsgaqvrpshfgafslgsrmspfssllgaraspiatgraglrfls
saapnpgkkpasaappagtnhgritqvigavvdvhfdeqlppilnslevqghtnrlvlev
aqhlgentvrtiamdateglvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvp
akktysihraaplfadqstepgllqtgikvvdllapyakggkiglfggagvgktvlimel
innvankhggfsvfagvgertregndlyhemmttgvikrkkledgkfdftgskaalvygq
mneppgararvaltalsvaeyfrdeqgqdvllfidniyrftqagsevsallgripsavgy
qptlatdlgqlqeritttkkgsitsvqavyvpaddltdpapattfahldattvlsrqiae
lgiypavdpldstsrmlapeivgqehydtaratqkllqdykslqdiiailgmdelseedk
lvvsrarkiqrflsqpftvaevftgkpgrfvelpetiksaqtilrgecddlpemafymcg
gleevrskavkmaqeaasgk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhF (F:)
nhgritqvigavvdvhfdeqlppilnslevqghtnrlvlevaqhlgentvrtiamdateg
lvrgqkvvdtgapiqvpvgvetlgrimnvigepvdecgpvpakktysihraaplfadqst
epgllqtgikvvdllapyakggkiglfggagvgktvlimelinnvankhggfsvfagvge
rtregndlyhemmttgvikrkkledgkfdftgskaalvygqmneppgararvaltalsva
eyfrdeqgqdvllfidniyrftqagsevsallgripsavgyqptlatdlgqlqeritttk
kgsitsvqavyvpaddltdpapattfahldattvlsrqiaelgiypavdpldstsrmlap
eivgqehydtaratqkllqdykslqdiiailgmdelseedklvvsrarkiqrflsqpftv
aevftgkpgrfvelpetiksaqtilrgecddlpemafymcggleevrskavkmaq

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'd':
    No sequence available.

  • Chain 'e':
    No sequence available.

  • Chain 'g':
    Sequence, based on SEQRES records: (download) 
    >6tmhg (g:)
maglaslssvgalrgmrlvpaahllplhsafgqqtrnfgagdlkivaarmksvksiqkit
kamkmvaasklrmdqrrlenglpfatpvqklvqripvdpkekgtlavlalssdkglcggv
nsfvakqarivikenemagnavqvygvgdkirsalqrtfgdrfkrimtevtrfpwnfgqa
ciiadrlmqdnparlmviynhfksavaydtltlnvltptqaaqsakeqlntfefepektd
vwkdlqdfyyactvfgcmldniaseqsarmsamdnastnagemissltlrynrarqakit
telveiisganale

    Sequence, based on observed residues (ATOM records): (download) 
    >6tmhg (g:)
dlkivaarmksvksiqkitkamkmvaasklrmdqrrlenglpfatpvqklvqripvdpke
kgtlavlalssdkglcggvnsfvakqarivikenemagnavqvygvgdkirsalqrtfgd
rfkrimtevtrfpwnfgqaciiadrlmqdnparlmviynhfksavaydtltlnvltptqa
aqsakeqlntfefepektdvwkdlqdfyyactvfgcmldniaseqsarmsamdnastnag
emissltlrynrarqakittelveiisganal

  • Chain 'i':
    No sequence available.