PDB entry 6hrd

View 6hrd on RCSB PDB site
Description: Crystal structure of M. tuberculosis FadB2 (Rv0468)
Class: oxidoreductase
Keywords: beta-oxidation, OXIDOREDUCTASE
Deposited on 2018-09-26, released 2019-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrda1, d6hrda2, d6hrda3
  • Chain 'B':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrdb1, d6hrdb2, d6hrdb3
  • Chain 'C':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrdc1, d6hrdc2, d6hrdc3
  • Chain 'D':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrdd1, d6hrdd2, d6hrdd3
  • Chain 'E':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrde1, d6hrde2, d6hrde3
  • Chain 'F':
    Compound: 3-hydroxybutyryl-CoA dehydrogenase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadB2, Rv0468
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNP7 (Start-305)
      • expression tag (306)
    Domains in SCOPe 2.08: d6hrdf1, d6hrdf2, d6hrdf3
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6hrdA (A:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdA (A:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6hrdB (B:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdB (B:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6hrdC (C:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdC (C:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6hrdD (D:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdD (D:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6hrdE (E:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdE (E:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6hrdF (F:)
mgsshhhhhhssglvprgshmsdaiqrvgvvgagqmgsgiaevsaragvevtvfepaeal
itagrnrivksleravsagkvtererdralglltfttdlndlsdrqlvieavvedeavks
eifaeldrvvtdpdavlasntssipimkvaaatkqpqrvlglhffnpvpvlplvelvrtl
vtdeaaaarteefastvlgkqvvrcsdrsgfvvnallvpyllsairmveagfatvedvdk
avvaglshpmgplrlsdlvgldtlkliadkmfeefkephygppplllrmveagqlgkksg
rgfytyaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6hrdF (F:)
daiqrvgvvgagqmgsgiaevsaragvevtvfepaealitagrnrivksleravsagkvt
ererdralglltfttdlndlsdrqlvieavvedeavkseifaeldrvvtdpdavlasnts
sipimkvaaatkqpqrvlglhffnpvpvlplvelvrtlvtdeaaaarteefastvlgkqv
vrcsdrsgfvvnallvpyllsairmveagfatvedvdkavvaglshpmgplrlsdlvgld
tlkliadkmfeefkephygppplllrmveagqlgkksgrgfytya