PDB entry 1xbp

View 1xbp on RCSB PDB site
Description: Inhibition of peptide bond formation by pleuromutilins: The structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with Tiamulin
Class: ribosome
Keywords: Tiamulin, Pleuromutilin, 50S RIBOSOME
Deposited on 2004-08-31, released 2005-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: 0.29
AEROSPACI score: -0 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '0':
    Compound: 23S ribosomal RNA
    Species: Deinococcus radiodurans [TaxId:1299]
  • Chain '1':
    Compound: 50S ribosomal protein L33
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbp11
  • Chain '2':
    Compound: 50S ribosomal protein L34
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbp21
  • Chain '3':
    Compound: 50S ribosomal protein L35
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbp31
  • Chain '4':
    Compound: 50S ribosomal protein L36
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbp41
  • Chain '9':
    Compound: 5S ribosomal RNA
    Species: Deinococcus radiodurans [TaxId:1299]
  • Chain 'A':
    Compound: 50S ribosomal protein L2
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpa1, d1xbpa2
  • Chain 'B':
    Compound: 50S ribosomal protein L3
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpb1
  • Chain 'C':
    Compound: 50S ribosomal protein L4
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpc1
  • Chain 'D':
    Compound: 50S ribosomal protein L5
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpd1
  • Chain 'E':
    Compound: 50S ribosomal protein L6
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpe1, d1xbpe2
  • Chain 'F':
    Compound: 50S ribosomal protein L9
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: 50S ribosomal protein L11
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpg1, d1xbpg2
  • Chain 'H':
    Compound: 50S ribosomal protein L13
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbph1
  • Chain 'I':
    Compound: 50S ribosomal protein L14
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpi1
  • Chain 'J':
    Compound: 50S ribosomal protein L15
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpj1
  • Chain 'K':
    Compound: ribosomal protein L16
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: 50S ribosomal protein L17
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpl1
  • Chain 'M':
    Compound: 50S ribosomal protein L18
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpm1
  • Chain 'N':
    Compound: 50S ribosomal protein L19
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpn1
  • Chain 'O':
    Compound: 50S ribosomal protein L20
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpo1
  • Chain 'P':
    Compound: 50S ribosomal protein L21
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpp1
  • Chain 'Q':
    Compound: 50S ribosomal protein L22
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpq1
  • Chain 'R':
    Compound: 50S ribosomal protein L23
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpr1
  • Chain 'S':
    Compound: 50S ribosomal protein L24
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbps1
  • Chain 'T':
    Compound: 50S ribosomal protein L25
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpt1
  • Chain 'U':
    Compound: 50S ribosomal protein L27
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpu1
  • Chain 'W':
    Compound: 50S ribosomal protein L29
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpw1
  • Chain 'X':
    Compound: 50S ribosomal protein L30
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpx1
  • Chain 'Y':
    Compound: 50S ribosomal protein L31
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Z':
    Compound: 50S ribosomal protein L32
    Species: Deinococcus radiodurans [TaxId:1299]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbpz1
  • Heterogens: MUL

PDB Chain Sequences:

  • Chain '0':
    No sequence available.

  • Chain '1':
    Sequence, based on SEQRES records: (download) 
    >1xbp1 (1:)
makdgpriivkmessagtgfyytttknrrntqaklelkkydpvakkhvvfrekkv

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbp1 (1:)
akdgpriivkmessagtgfyytttknrrntqaklelkkydpvakkhvvfrekk

  • Chain '2':
    Sequence, based on SEQRES records: (download) 
    >1xbp2 (2:)
mkrtyqpnnrkrakthgfrarmktksgrnilarrrakgrhqltvsde

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbp2 (2:)
mkrtyqpnnrkrakthgfrarmktksgrnilarrrakgrhqltvsd

  • Chain '3':
    Sequence, based on SEQRES records: (download) 
    >1xbp3 (3:)
pkmkthkmakrrikitgtgkvmafksgkrhqntgksgdeirgkgkgfvlakaewarmklm
lprgk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbp3 (3:)
pkmkthkmakrrikitgtgkvmafksgkrhqntgksgdeirgkgkgfvlakaewarmklm
lpr

  • Chain '4':
    Sequence, based on SEQRES records: (download) 
    >1xbp4 (4:)
mkvrssvkkmcdnckvvrrhgrvlvicsnvkhkqrqg

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbp4 (4:)
kvrssvkkmcdnckvvrrhgrvlvicsnvkhkqrq

  • Chain '9':
    No sequence available.

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xbpA (A:)
avkkyrpytpsrrqmttadfsgltkkrpekaltealpktggrnnrgritsrfiggghkrl
yriidfkrrdksgvnakvaaieydpnrsariallhyadgekryilapegltvgatvnagp
eaepklgnalplrfvpvgavvhalelvpgkgaqlarsagtsvqvqgkesdyvivrlpsge
lrrvhsecyatigavgnaehknivlgkagrsrwlgrkphqrgsamnpvdhphgggegrtg
agrvpvtpwgkptkglktrrkrktsdrfivtrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpA (A:)
kkyrpytpsrrqmttadfsgltkkrpekaltealpktggrnnrgritsrfiggghkrlyr
iidfkrrdksgvnakvaaieydpnrsariallhyadgekryilapegltvgatvnagpea
epklgnalplrfvpvgavvhalelvpgkgaqlarsagtsvqvqgkesdyvivrlpsgelr
rvhsecyatigavgnaehknivlgkagrsrwlgrkphqrgsamnpvdhphgggegrtgag
rvpvtpwgkptkglktrrkrktsdrfivtr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xbpB (B:)
mkgilgtkigmtqiwkndraipvtvvlagpcpivqrktaqtdgyeavqigyapkaerkvn
kpmqghfakagvaptrilrefrgfapdgdsvnvdifaegekidatgtskgkgtqgvmkrw
nfaggpashgskkwhrrpgsigqrktpgrvykgkrmaghmgmervtvqnlevveiragen
lilvkgaipgangglvvlrsaakasaakggk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpB (B:)
mkgilgtkigmtqiwkndraipvtvvlagpcpivqrktaqtdgyeavqigyapkaerkvn
kpmqghfakagvaptrilrefrgfapdgdsvnvdifaegekidatgtskgkgtqgvmkrw
nfaggpashgskkwhrrpgsigqrktpgrvykgkrmaghmgmervtvqnlevveiragen
lilvkgaipgangglvvlrsaakas

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1xbpC (C:)
aqinvigqnggrtielplpevnsgvlhevvtwqlasrrrgtastrtraqvsktgrkmygq
kgtgnarhgdrsvptfvgggvafgpkprsydytlprqvrqlglamaiasrqeggklvavd
gfdiadaktknfiswakqngldgtekvllvtddentrraarnvswvsvlpvagvnvydil
rhdrlvidaaaleiveeeageeqq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpC (C:)
aqinvigqnggrtielplpevnsgvlhevvtwqlasrrrgtastrtraqvsktgrkmygq
kgtgnarhgdrsvptfvgggvafgpkprsydytlprqvrqlglamaiasrqeggklvavd
gfdiadaktknfiswakqngldgtekvllvtddentrraarnvswvsvlpvagvnvydil
rhdrlvidaaaleivee

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1xbpD (D:)
mqqlktkyndqvrpalmqqfgyssvmavpriekivvneglgsskedskaidkaakelali
tlqkpiitkakksisnfklrqgmpvgikvtlrgermyvflekliniglprirdfrginpn
afdgrgnynlgikeqlifpeitydmvdktrgmditivttaktdeearallqsmglpfrkq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpD (D:)
qqlktkyndqvrpalmqqfgyssvmavpriekivvneglgsskedskaidkaakelalit
lqkpiitkakksisnfklrqgmpvgikvtlrgermyvflekliniglprirdfrginpna
fdgrgnynlgikeqlifpeitydmvdktrgmditivttaktdeearallqsmglpfrk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1xbpE (E:)
msrigkqpiavpsgvtvnaqdgvfkvkgpkgeltvpynteltvrqdgdqllverpsdaqk
hralhgltrtlvanavkgvsdgytinlelrgvgfrakltgkalemnigyshpviieppag
vtfavpeptridvsgidkqlvgqvaanvrkvrkpdayhgkgvrfvgeqialkagkagatg
gkgkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpE (E:)
gkqpiavpsgvtvnaqdgvfkvkgpkgeltvpynteltvrqdgdqllverpsdaqkhral
hgltrtlvanavkgvsdgytinlelrgvgfrakltgkalemnigyshpviieppagvtfa
vpeptridvsgidkqlvgqvaanvrkvrkpdayhgkgvrfvgeqialkagkagatgg

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1xbpG (G:)
mkkvagivklqlpagkatpappvgpalgqyganimeftkafnaqtadkgdaiipveitiy
adrsftfitktppmsylirkaagigkgsstpnkakvgklnwdqvleiaktkmpdlnagsv
eaaantvagtarsmgvtveggpna

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpG (G:)
mkkvagivklqlpagkatpappvgpalgqyganimeftkafnaqtadkgdaiipveitiy
adrsftfitktppmsylirkaagigkgsstpnkakvgklnwdqvleiaktkmpdlnagsv
eaaantvagtarsmgvtveggpn

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1xbpH (H:)
mafpdtdvspprggpsspakspllrsfkvktyipkndeqnwvvvdasgvplgrlatlias
rirgkhrpdftpnmiqgdfvvvinaaqvaltgkklddkvytrytgyqgglktetareals
khperviehavfgmlpkgrqgramhtrlkvyagethphsaqkpqvlktqplevk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpH (H:)
vktyipkndeqnwvvvdasgvplgrlatliasrirgkhrpdftpnmiqgdfvvvinaaqv
altgkklddkvytrytgyqgglktetarealskhperviehavfgmlpkgrqgramhtrl
kvyagethphsaqkpqvlktqpl

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1xbpI (I:)
mimpqsrldvadnsgareimcirvlnsgiggkglttggggnkryahvgdiivasvkdaap
rgavkagdvvkavvvrtshaikradgstirfdrnaaviinnqgeprgtrvfgpvarelrd
rrfmkivslapevl

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpI (I:)
impqsrldvadnsgareimcirvlnsgiggkglttggggnkryahvgdiivasvkdaapr
gavkagdvvkavvvrtshaikradgstirfdrnaaviinnqgeprgtrvfgpvarelrdr
rfmkivslapev

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1xbpJ (J:)
mklhdlkptpgsrkdrkrvgrgpggtdktagrghkgqksrsgagkgaffeggrsrliarl
pkrgfnnvgttyevvklsqlqdledttfdrdtleayrlvrrknrpvkllasgeisravtv
hvdaasaaaikaveaaggrvvlpevqtqqddaqkae

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpJ (J:)
hdlkptpgsrkdrkrvgrgpggtdktagrghkgqksrsgagkgaffeggrsrliarlpkr
gfnnvgttyevvklsqlqdledttfdrdtleayrlvrrknrpvkllasgeisravtvhvd
aasaaaikaveaaggrvvlpe

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1xbpL (L:)
mrhgkagrklnrnssarvalaraqatallregriqttltkakelrpfveqlittakggdl
hsrrlvaqdihdkdvvrkvmdevapkyaerpggytrilrvgtrrgdgvtmalielv

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpL (L:)
hgkagrklnrnssarvalaraqatallregriqttltkakelrpfveqlittakggdlhs
rrlvaqdihdkdvvrkvmdevapkyaerpggytrilrvgtrrgdgvtmalielv

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >1xbpM (M:)
atattirrklrtrrkvrtttaasgrlrlsvyrsskhiyaqiiddsrgqtlaaassaalks
gnktdtaaavgkalaaaaaekgikqvvfdrgsykyhgrvkaladaareggldf

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpM (M:)
attirrklrtrrkvrtttaasgrlrlsvyrsskhiyaqiiddsrgqtlaaassaalksgn
ktdtaaavgkalaaaaaekgikqvvfdrgsykyhgrvkaladaareggldf

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >1xbpN (N:)
mqthikinrgellrgieqdhtrqlpdfrpgdtvrvdtkvregnrtrsqafegvviaings
gsrksftvrkisfgegvervfpfasplvnqvtivergkvrraklyylrelrgkaariksd
rsrvmkdaaraqqdkanasasqaaaaqadvtvisaapevapetqge

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpN (N:)
qthikinrgellrgieqdhtrqlpdfrpgdtvrvdtkvregnrtrsqafegvviaingsg
srksftvrkisfgegvervfpfasplvnqvtivergkvrraklyylrelrgkaariksdr
srvmk

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >1xbpO (O:)
mpraktgivrrrrhkkvlkrakgfwgsrskqyrnafqtllnaatyeyrdrrnkkrdfrrl
wiqrinagarlhgmnystfinglkranidlnrkvladiaarepeafkalvdasrnarq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpO (O:)
praktgivrrrrhkkvlkrakgfwgsrskqyrnafqtllnaatyeyrdrrnkkrdfrrlw
iqrinagarlhgmnystfinglkranidlnrkvladiaarepeafkalvdasrnarq

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1xbpP (P:)
mfaiiqtggkqyrvsegdvirveslqgeagdkvelkalfvggeqtvfgedagkytvqaev
vehgrgkkiyirkyksgvqyrrrtghrqnftaikilgiqg

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >1xbpQ (Q:)
mtapeqtfrnkkqrkqqvklrkpgfavakyvrmsprkvrlvvdvirgksvqdaedllrfi
prsasepvakvlnsakanalhndemledrlfvkeayvdagptlkrliprargsaniikkr
tshitiivaekgnk

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpQ (Q:)
frnkkqrkqqvklrkpgfavakyvrmsprkvrlvvdvirgksvqdaedllrfiprsasep
vakvlnsakanalhndemledrlfvkeayvdagptlkrliprargsaniikkrtshitii
vaekgnk

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >1xbpR (R:)
shydilqapvisekaysamergvysfwvspkatkteikdaiqqafgvrvigistmnvpgk
rkrvgrfigqrndrkkaivrlaegqsiealagqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpR (R:)
shydilqapvisekaysamergvysfwvspkatkteikdaiqqafgvrvigistmnvpgk
rkrvgrfigqrndrkkaivrlaegqsiealagq

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >1xbpS (S:)
mprpsagshhndklhfkkgdtvivlsgkhkgqtgkvllalprdqkvvvegvnvitknvkp
smtnpqggqeqrelalhaskvalvdpetgkatrvrkqivdgkkvrvavasgktid

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpS (S:)
prpsagshhndklhfkkgdtvivlsgkhkgqtgkvllalprdqkvvvegvnvitknvkps
mtnpqggqeqrelalhaskvalvdpetgkatrvrkqivdgkkvrvavasgkti

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >1xbpT (T:)
meltakprtpkqkldesmiaavaynkennvsfaldrkafdrafrqqsttglfditvegge
tfpalvkavqmdkrkrapihvdfymvtygepvevsvpvhttgrsqgevqgglvdivvhnl
qivapgprripqelvvdvtkmnigdhitagdiklpegctlaadpeltvvsvlpprltaee
leaevqaaqvaglvaagelseeaaeavlegdasleevkaeasednagtdsednsdaq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpT (T:)
meltakprtpkqkldesmiaavaynkennvsfaldrkafdrafrqqsttglfditvegge
tfpalvkavqmdkrkrapihvdfymvtygepvevsvpvhttgrsqgevqgglvdivvhnl
qivapgprripqelvvdvtkmnigdhitagdiklpegctlaadpeltvvsvlpprltaee
leaevqaaqvaglvaagelseeaaeavlegdasleevkaease

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >1xbpU (U:)
mahkkgvgsskngrdsnpkylgvkkfggevvkagnilvrqrgtkfkagqgvgmgrdhtlf
alsdgkvvfinkgkgarfisieaaqtevaad

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpU (U:)
ahkkgvgsskngrdsnpkylgvkkfggevvkagnilvrqrgtkfkagqgvgmgrdhtlfa
lsdgkvvfinkgkgarfisieaaqte

  • Chain 'W':
    Sequence, based on SEQRES records: (download) 
    >1xbpW (W:)
mkpsemrnlqatdfakeidarkkelmelrfqaaagqlaqphrvrqlrrevaqlntvkael
arkgeqq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpW (W:)
kpsemrnlqatdfakeidarkkelmelrfqaaagqlaqphrvrqlrrevaqlntvkaela
rkgeq

  • Chain 'X':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1xbpX (X:)
mkiklvrsvigrpgnqvktvqalglrkigdsrevsdtpavrgmvktvkhllevqe

  • Chain 'Y':
    No sequence available.

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >1xbpZ (Z:)
akhpvpkkktskskrdmrrshhaltapnltecpqchgkklshhicpncgyydgrqvlav

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbpZ (Z:)
akhpvpkkktskskrdmrrshhaltapnltecpqchgkklshhicpncgyydgrqvla