SCOPe 2.05: Domain d1os5a_: 1os5 A:

Lineage for d1os5a_ (1os5 A:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d1os5a_: 1os5 A: [93475]
   protein/RNA complex; complexed with nh1

Details for d1os5a_

PDB Entry: 1os5, 2.2 Å

PDB Description: crystal structure of hcv ns5b rna polymerase complexed with a novel non-competitive inhibitor.

PDB Compounds: (A:) hepatitis c virus ns5b RNA polymerase

SCOPe Domain Sequences for d1os5a_:

Sequence; same for both SEQRES and ATOM records:

>d1os5a_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhs

Timeline for d1os5a_:

• d1os5a_ first appeared in SCOP 1.67
  
• d1os5a_ appears in SCOPe 2.04
  
• d1os5a_ appears in SCOPe 2.06
  
• d1os5a_ appears in the current release, SCOPe 2.08