SCOPe is a database developed at the Berkeley Lab and UC Berkeley that extends SCOP (version 1). SCOPe classifies many structures released since SCOP 1.75 through a combination of automation and manual curation, and corrects some errors, aiming to have the same accuracy as the fully hand-curated SCOP releases. SCOPe also incorporates and updates the Astral database.
In addition to new SCOPe releases, the SCOPe website provides integrated access to data found in all releases of the SCOP and Astral databases that feature stable identifiers (i.e., those since release 1.55). A history of all changes between consecutive releases of SCOP and SCOPe is available under the Stats & History menu.
In order to facilitate use of SCOPe data by SCOP and Astral users, we provide SCOPe data in parseable files in the same formats as the SCOP and Astral databases. SCOPe uses the same stable identifiers (e.g., sunid, sid, sccs) as were used for prior releases of SCOP and Astral.
In SCOPe 2.05, we have continued to perform manual curation of new Folds, Superfamilies, and Families. We also have begun testing a hybrid curation system, in which predictions made by our automated method that are not high-confidence are verified and corrected by human curators, prior to adding the domains to SCOPe.
All data in SCOPe (including the data from older releases of SCOP and Astral) are freely available to all users.
There are several alternative pronunciations of the vowels in the word SCOPe. All are considered correct.