SCOPe 2.05: Domain d1p22a1: 1p22 A:135-252

Lineage for d1p22a1 (1p22 A:135-252)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.158: F-box domain [81385] (1 superfamily)
   multihelical; interlocked heterodimer with the Skp1 dimerisation domain

4. Superfamily a.158.1: F-box domain [81383] (1 family)

5. Family a.158.1.1: F-box domain [81381] (4 proteins)

6. Protein F-box/WD-repeat protein 1 (beta-TRCP1) [89138] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89139] (1 PDB entry)

8. Domain d1p22a1: 1p22 A:135-252 [87715]
   Other proteins in same PDB: d1p22a2, d1p22b1, d1p22b2

Details for d1p22a1

PDB Entry: 1p22, 2.95 Å

PDB Description: Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase

PDB Compounds: (A:) F-box/WD-repeat protein 1A

SCOPe Domain Sequences for d1p22a1:

Sequence, based on SEQRES records:

>d1p22a1 a.158.1.1 (A:135-252) F-box/WD-repeat protein 1 (beta-TRCP1) {Human (Homo sapiens) [TaxId: 9606]}
spaimlqrdfitalpargldhiaenilsyldakslcaaelvckewyrvtsdgmlwkklie
rmvrtdslwrglaerrgwgqylfknkppdgnappnsfyralypkiiqdietiesnwrc

Sequence, based on observed residues (ATOM records):

>d1p22a1 a.158.1.1 (A:135-252) F-box/WD-repeat protein 1 (beta-TRCP1) {Human (Homo sapiens) [TaxId: 9606]}
spaimlqrdfitalpargldhiaenilsyldakslcaaelvckewyrvtsdgmlwkklie
rmvrtdslwrglaerrgwgqylfppnsfyralypkiiqdietiesnwrc

Timeline for d1p22a1:

• d1p22a1 first appeared in SCOP 1.65
  
• d1p22a1 appears in SCOPe 2.04
  
• d1p22a1 appears in SCOPe 2.06
  
• d1p22a1 appears in the current release, SCOPe 2.08