SCOPe 2.06: Family g.37.1.1: Classic zinc finger, C2H2

Lineage for Family g.37.1.1: Classic zinc finger, C2H2

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.37: beta-beta-alpha zinc fingers [57666] (1 superfamily)
   simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC

4. Superfamily g.37.1: beta-beta-alpha zinc fingers [57667] (8 families)

5. Family g.37.1.1: Classic zinc finger, C2H2 [57668] (31 proteins)

Proteins:

1. ADR1 [57675] (1 species)

   • Species Synthetic, based on Saccharomyces cerevisiae sequence [57676] (5 PDB entries)

2. Enhancer binding protein [57685] (1 species)
   duplication: consists of two Zn fingers

   • Species Human (Homo sapiens) [TaxId:9606] [57686] (3 PDB entries)

3. Five-finger GLI1 [57683] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57684] (1 PDB entry)

4. GAGA factor [57695] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [57696] (2 PDB entries)

5. GLI-Krueppel family member HKR3 [144147] (1 species)
   ZBTB48

   • Species Mouse (Mus musculus) [TaxId:10090] [144148] (1 PDB entry)
     Uniprot Q1H9T6 284-310! Uniprot Q1H9T6 311-338! Uniprot Q1H9T6 339-368! Uniprot Q1H9T6 369-394

6. Kruppel-like factor 3, Bklf [103597] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [103598] (3 PDB entries)

7. PATZ1 [161152] (1 species)
   Zinc finger protein 278

   • Species Human (Homo sapiens) [TaxId:9606] [161153] (5 PDB entries)
     Uniprot Q9HBE1 286-338! Uniprot Q9HBE1 350-384! Uniprot Q9HBE1 355-379! Uniprot Q9HBE1 380-409! Uniprot Q9HBE1 380-411! Uniprot Q9HBE1 407-445! Uniprot Q9HBE1 410-436

8. SWI5 zinc-finger domains [57681] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [57682] (2 PDB entries)

9. Tramtrack protein (two zinc-finger peptide) [57673] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [57674] (1 PDB entry)

10. Transactivation domain of cre-bp1/atf-2 [57689] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57690] (1 PDB entry)

11. Transcription factor IIIA, TFIIIA [57693] (1 species)
    duplication: consists of 6 fingers

    • Species African clawed frog (Xenopus laevis) [TaxId:8355] [57694] (4 PDB entries)

12. Transcription factor sp1 [57687] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57688] (4 PDB entries)

13. Transcriptional repressor CTCF [144153] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144154] (2 PDB entries)
      Uniprot P49711 399-434! Uniprot P49711 435-462! Uniprot P49711 515-550! Uniprot P49711 551-587

14. V(D)J recombination activating protein 1 (RAG1), dimerization domain [57671] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [57672] (1 PDB entry)

15. Wilms' tumor protein, WT1 [118269] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [118270] (1 PDB entry)
      Uniprot P19544 381-408

16. XFIN, third domain [57677] (1 species)

    • Species African clawed frog (Xenopus laevis) [TaxId:8355] [57678] (1 PDB entry)

17. Ying-yang 1 (yy1, zinc finger domain) [57691] (1 species)
    duplication: consists of 4 fingers

    • Species Human (Homo sapiens) [TaxId:9606] [57692] (1 PDB entry)

18. ZFY [57679] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57680] (5 PDB entries)
      Uniprot P08048 570-598

19. ZIF268 [57669] (1 species)
    duplication: consists of 3 fingers

    • Species Mouse (Mus musculus) [TaxId:10090] [57670] (14 PDB entries)

20. Zinc finger and SCAN domain-containing protein 16, ZSCAN16 [144155] (1 species)
    Zinc finger protein 435

    • Species Human (Homo sapiens) [TaxId:9606] [144156] (1 PDB entry)
      Uniprot Q9H4T2 224-261! Uniprot Q9H4T2 262-288

21. Zinc finger protein 24 [144143] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144144] (1 PDB entry)
      Uniprot P17028 272-304! Uniprot P17028 305-330

22. Zinc finger protein 292, ZNF292 [144133] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144134] (1 PDB entry)
      Uniprot O60281 1340-1400

23. Zinc finger protein 295, ZNF295 [118267] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [118268] (1 PDB entry)
      Uniprot Q9ULJ3 713-806

24. Zinc finger protein 297b [144145] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144146] (1 PDB entry)
      Uniprot O43298 370-422! Uniprot O43298 423-486

25. Zinc finger protein 462, ZNF462 [144137] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144138] (1 PDB entry)
      Uniprot Q96JM2 719-793

26. Zinc finger protein 512, ZNF512 [144135] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144136] (1 PDB entry)
      Uniprot Q96ME7 142-194! Uniprot Q96ME7 195-224

27. Zinc finger protein 64, ZFP68 [144149] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144150] (2 PDB entries)
      Uniprot Q9NPA5 174-199! Uniprot Q9NPA5 200-227! Uniprot Q9NPA5 228-256! Uniprot Q9NPA5 341-368! Uniprot Q9NPA5 369-397

28. Zinc finger protein 692, ZNF692 [144139] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144140] (1 PDB entry)
      Uniprot Q9BU19 328-357! Uniprot Q9BU19 358-393

29. Zinc finger protein ZFPM1 (FOG-1) [111434] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [111435] (1 PDB entry)
      Uniprot O35615 328-360

30. Zinc fingers and homeoboxes protein 1, ZHX1 [144141] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [144142] (1 PDB entry)
      Uniprot Q9UKY1 60-95! Uniprot Q9UKY1 96-153

31. automated matches [192458] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [161316] (92 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [161315] (1 PDB entry)

More info for Family g.37.1.1: Classic zinc finger, C2H2

Timeline for Family g.37.1.1: Classic zinc finger, C2H2:

• Family g.37.1.1: Classic zinc finger, C2H2 first appeared (with stable ids) in SCOP 1.55
  
• Family g.37.1.1: Classic zinc finger, C2H2 appears in SCOPe 2.05
  
• Family g.37.1.1: Classic zinc finger, C2H2 appears in SCOPe 2.07
  
• Family g.37.1.1: Classic zinc finger, C2H2 appears in the current release, SCOPe 2.08