SCOPe 2.06: Superfamily g.37.1: beta-beta-alpha zinc fingers

Lineage for Superfamily g.37.1: beta-beta-alpha zinc fingers

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.37: beta-beta-alpha zinc fingers [57666] (1 superfamily)
   simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC

4. Superfamily g.37.1: beta-beta-alpha zinc fingers [57667] (8 families)

Families:

1. g.37.1.1: Classic zinc finger, C2H2 [57668] (31 proteins)

2. g.37.1.2: C2HC finger [57697] (3 proteins)

3. g.37.1.3: Plant C2H2 finger (QALGGH zinc finger) [90198] (1 protein)

4. g.37.1.4: HkH motif-containing C2H2 finger [111436] (4 proteins)
   putative dsRNA-specific zinc finger with a helix-kink-helix (HkH) motif; the kink results from the incompatibility of the cation-coordinating H-x5-H motif with a regular alpha-helix and contributes to RNA recognition

5. g.37.1.5: variant C2H2 finger [118273] (1 protein)
   contains extra C-terminal, alpha-helical subdomain

6. g.37.1.6: BED zinc finger [144157] (1 protein)
   Pfam PF02892; contains extra N-terminal and C-terminal helices bundled together with the core helix

7. g.37.1.7: CHHC finger [161158] (1 protein)

8. g.37.1.0: automated matches [196454] (1 protein)
   not a true family

More info for Superfamily g.37.1: beta-beta-alpha zinc fingers

Timeline for Superfamily g.37.1: beta-beta-alpha zinc fingers:

• Superfamily g.37.1: beta-beta-alpha zinc fingers first appeared (with stable ids) in SCOP 1.55, called Superfamily g.37.1: C2H2 and C2HC zinc fingers
  
• Superfamily g.37.1: beta-beta-alpha zinc fingers appears in SCOPe 2.05
  
• Superfamily g.37.1: beta-beta-alpha zinc fingers appears in SCOPe 2.07
  
• Superfamily g.37.1: beta-beta-alpha zinc fingers appears in the current release, SCOPe 2.08